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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Govatati, Suresh Malempati, Sravanthi Saradamma, Bulle Divyamaanasa, Dasi Naidu, B. Prathap Bramhachari, Pallaval Veera Narayana, Nagesh Shivaji, Sisinthy Bhanoori, Manjula Tamanam, Raghava Rao Rao, Pasupuleti Sreenivasa Nallanchakravarthula, Varadacharyulu |
| Description | Country affiliation: India Author Affiliation: Govatati S ( Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515 003, India.); Malempati S ( Department of Biochemistry, Dr. MRAR PG Center, Krishna University, Nuzvid, India.); Saradamma B ( Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515 003, India.); Divyamaanasa D ( Gandhi Institute of Technology and Management Dental College, Visakhapatnam, India.); Naidu BP ( Department of Biotechnology, Krishna University, Machilipatnam, India.); Bramhachari PV ( Department of Biotechnology, Krishna University, Machilipatnam, India.); Narayana N ( CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.); Shivaji S ( CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.); Bhanoori M ( Presently at: Jhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad, India.); Tamanam RR ( Department of Biochemistry, Osmania University, Hyderabad, India.); Rao PS ( Department of Biochemistry, Andhra University, Visakhapatnam, India.); Nallanchakravarthula V ( Department of Advanced Research Centre, Narayana Medical College and Hospitals, Nellore, India.) |
| Abstract | Mitochondrial displacement loop (D-loop) is a hot spot for mitochondrial DNA (mtDNA) alterations that effects cellular reactive oxygen species (ROS) generation. Manganese-superoxide dismutase (Mn-SOD) is a major antioxidant enzyme that protects cells from ROS-mediated damage. In the present study, we investigated the relationship between sequence alterations of mitochondrial D-loop and Mn-SOD expression in colorectal cancer (CRC). Genotyping of entire mitochondrial D-loop (1124 bp) was carried out on mtDNA of analogous tumor and normal tissues from 35 CRC patients of south Indian origin by PCR-sequencing analysis. Tumor-specific large-scale mtDNA deletions and Mn-SOD expression was analyzed by PCR and Western blot analysis, respectively. We identified 87 polymorphisms in the D-loop region of tumor and/or control tissues. Polymorphisms were predominantly located in hypervariable region I (67.9 %) than in II (32.1 %) of D-loop. Significantly increased mtDNA microsatellite instability (mtMSI) [310'C' insertion (P = 0.00001) and T16189C (P = 0.0007)] and elevated Mn-SOD expression was observed in tumor tissues compared with controls. Interestingly, mtMSI was significantly high in tumors with Mn-SOD overexpression. Tumor-specific large-scale mtDNA deletions were not observed in CRC tissues. In conclusion, mtMSI and Mn-SOD overexpression are a common event in CRC. The analysis of mtMSI and/or Mn-SOD expression might help to identify patients at high risk for disease outcome, thereby helping to refine therapeutic decisions in CRC. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 8 |
| Journal | Tumor Biology |
| Volume Number | 37 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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