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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lima, Géssica Santos, Erinaldo Angelo, Hildson Oliveira, Micheline Heráclio, Sandra Leite, Fernanda de Melo, Celso Crovella, Sergio Maia, Maria Souza, Paulo |
| Description | Country affiliation: Brazil Author Affiliation: Lima G ( Post-Graduate Program in Cellular and Molecular Biology Applied, University of Pernambuco (UPE), Recife, PE, Brazil.); Santos E ( Post-Graduate Program in Tropical Animal Science, Rural Federal University of Pernambuco (UFRPE), Recife, PE, Brazil.); Angelo H ( Post-Graduate Program in Genetic, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.); Oliveira M ( Federal Institute of Pernambuco - Campus Garanhuns (IFPE/Garanhuns), Garanhuns, PE, Brazil.); Heráclio S ( Post-Graduate Program in Biological Science, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.); Leite F ( Departament of Lower Genital Tract Pathology, Women's Healthcare Center, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.); de Melo C ( Department of Biology, Rural Federal University of Pernambuco (UFRPE), Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900, Recife, PE, Brazil.); Crovella S ( Departament of Physics, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.); Maia M ( Post-Graduate Program in Genetic, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.); Souza P ( Departament of Genetics, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.) |
| Abstract | Infection by high-risk human papillomavirus (HR-HPV) and single nucleotide polymorphism (SNP) in genes involved in cell cycle control, as p21 and p27, are important factors in the development of different types of human cancers. This study aims at investigating whether both the p21 Ser31Arg and p27 V109G polymorphisms are associated with susceptibility to the development of cervical lesions in women HR-HPV positive. We analyzed 132 women HPV positive and with cervical lesions or CC and 154 healthy control (HPV negative and without cervical lesions). p21 Ser31Arg and p27 V109G polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and sequencing. The p21 31Arg allele was associated with susceptibility for the development of cervical lesions (P* = 0.0009), while p27 V109G polymorphism showed no significant differences for this association (P* = 0.89). However, the combined effect of the polymorphisms showed that the presence of the CC genotype (SNP p21 Ser31Arg) conferred protection for the development of cervical lesions (OR = 0.39). p21 Ser31Arg and p27 V109G polymorphisms were not associated with the grade of cervical lesions (CINI, CINII, and CINIII) or CC (P* > 0.05). The HR-HPV more frequent in this study were of 16 (57.6 %) and 18 (37.1 %) types; however, no association was observed when both polymorphisms and risk factors analyzed were compared (P* > 0.05). Our findings suggest a possible association between p21 Ser31tabArg polymorphism and susceptibility to the development of cervical lesions in women from Pernambuco. Brazil. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 8 |
| Journal | Tumor Biology |
| Volume Number | 37 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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