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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Shu Guo, Ling-Ji Zhang, Gang Wang, Ling-Li Hao, Shuai Gao, Bo Jiang, Yan Tian, Wu-Guo Cao, Xian-E Luo, Dong-Lin |
| Description | Author Affiliation: Zhang S ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Guo LJ ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Zhang G ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Wang LL ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Hao S ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Gao B ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Jiang Y ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Tian WG ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Cao XE ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China.); Luo DL ( Department of Breast, Thyroid, and Vascular Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Changjiangzhi Road, No 10, Yuzhong Area, Chongqing, 400042, People's Republic of China. LDL_dongDD@163.com.) |
| Abstract | The aim of the study is to explore roles of microRNA (miR)-124a and miR-30d in breast cancer (BC) patients with type 2 diabetes mellitus (T2DM). A total of 144 cases of confirmed diagnosed BC with T2DM, T2DM, BC, or healthy people were enrolled. Among them, BC patients with T2DM were regarded as the experiment group (n = 36), patients with T2DM as the Dm group (n = 36), patients with BC as the Bc group (n = 36), and healthy subjects as the healthy group (n = 36). The fasting insulin resistance index, glycosylated hemoglobin, and estradiol were measured. MiR-124a and miR-30d expressions were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The insulin resistance index was significantly higher in the experiment group compared to the other three groups (all P < 0.05). The glycated hemoglobin was in a normal range in the Bc group and healthy group, but was higher in the experiment group and the Bc group compared to that in the healthy group (both P < 0.05). The serum estradiol level was obviously higher in the Bc group compared with that in the Dm group and the experiment group (both P < 0.05). The expressions of miR-124a and miR-30d were positively correlated with insulin resistance index, BMI and glycosylated hemoglobin (miR-124a r = 0.659, r = 0.785, and r = 0.862; miR-30d r = 0.742, r = 0.805, r = 0.765; all P < 0.001). Insulin resistance index was an independent factor for expressions of miR124-a and miR-30d. MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. Although the mechanism is not clear, miR-124a and miR-30d potentially may be used as therapeutic targets and prognostic markers for BC patients with T2DM. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 8 |
| Journal | Tumor Biology |
| Volume Number | 37 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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