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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sinha, Priyanka Ubaidulla, U. Hasnain, M. Saquib Nayak, Amit Kumar Rama, Bobba |
| Description | Country affiliation: India Author Affiliation: Sinha P ( Department of Pharmaceutics, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Rajiv Gandhi Salai, Thorapakkam, Chennai 600097, India.); Ubaidulla U ( Department of Pharmaceutics, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Rajiv Gandhi Salai, Thorapakkam, Chennai 600097, India.); Hasnain MS ( Department of Pharmacy, B. B. S. Institute of Pharmaceutical and Allied Science, Greater Noida 201310, India.); Nayak AK ( Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.); Rama B ( Department of Pharmaceutics, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Rajiv Gandhi Salai, Thorapakkam, Chennai 600097, India.) |
| Abstract | Zinc (Zn(2+))-ion induced diclofenac sodium (DS)-loaded alginate-okra (Hibiscus esculentus) gum (OG) blend beads was successfully formulated through Zn(2+)-ion induced ionic-gelation cross-linking method in a complete aqueous environment. Effects of polymer-blend ratio and cross-linker concentration on drug encapsulation efficiency (DEE) and cumulative drug release at 8 h (R8h) were optimized by 3(2)-factorial design. The optimized formulation of Zn(2+)-ion induced DS-loaded alginate-OG beads demonstrated 89.27±3.58% of DEE and 43.73±2.83% of R8h. The bead sizes were within 1.10±0.07 to 1.38±0.14 mm. The bead surface morphology was analyzed by SEM. The drug-polymer interaction in the optimized bead matrix was analyzed by FTIR and P-XRD. These beads exhibited sustained in vitro drug release over a prolonged period of 8h and followed controlled-release (zero-order) pattern with super case-II transport mechanism. The swelling and degradation of the optimized beads was influenced by the pH of test mediums, which might be suitable for intestinal drug delivery. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 79 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Alginates Chemistry Anti-inflammatory Agents, Non-steroidal Diclofenac Plant Gums Abelmoschus Delayed-action Preparations Fruit Hydrogen-ion Concentration Microspheres X-ray Diffraction Zinc Sulfate Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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