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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Martins, Alessandro F. Follmann, Heveline D. M. Monteiro, Johny P. Bonafé, Elton G. Nocchi, Samara Silva, Cleiser T. P. Nakamura, Celso V. Girotto, Emerson M. Rubira, Adley F. Muniz, Edvani C. |
| Description | Author Affiliation: Martins AF ( Departamento de Química, Universidade Tecnológica Federal do Paraná (UTFPR), Apucarana 86812-1200, Brazil); Follmann HD ( Grupo de Materiais Poliméricos e Compósitos, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.); Monteiro JP ( Departamento de Química, Universidade Tecnológica Federal do Paraná (UTFPR), Apucarana 86812-1200, Brazil); Bonafé EG ( Departamento de Química, Universidade Tecnológica Federal do Paraná (UTFPR), Apucarana 86812-1200, Brazil); Nocchi S ( Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.); Silva CT ( Grupo de Materiais Poliméricos e Compósitos, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.); Nakamura CV ( Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.); Girotto EM ( Grupo de Materiais Poliméricos e Compósitos, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.); Rubira AF ( Grupo de Materiais Poliméricos e Compósitos, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.); Muniz EC ( Grupo de Materiais Poliméricos e Compósitos, Universidade Estadual de Maringá (UEM), Maringá 87020-900, Brazil.) |
| Abstract | Polyelectrolyte complex (beads) based on N,N,N-trimethyl chitosan/alginate was successful obtained and silver nanoparticles (AgNPs) were loaded within beads. In vitro cytotoxicity assays using beads/silver nanoparticles (beads/AgNPs) provided results, indicating that this material significantly inhibited the growth of colon cancer cells (Caco-2). In vitro release studies showed that the beads stabilized AgNPs and repressed Ag(0) oxidation under gastric conditions (pH 2.0). On the other hand, at physiological condition (pH 7.4) the beads/AgNPs released 3.3 µg of Ag(+) per each beads milligram. These studies showed that the concentration of Ag(+) released (3.3 µg) was cytotoxic for the Caco-2 cells and was not cytotoxic on healthy VERO cells. This result opens new perspectives for the manufacture of biomaterials based on beads/AgNPs with anti-tumor properties. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 79 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Antineoplastic Agents Pharmacology Biocompatible Materials Chitosan Chemistry Metal Nanoparticles Silver Animals Biomimetic Materials Caco-2 Cells Cercopithecus Aethiops Drug Liberation Gastric Juice Humans Hydrogen-ion Concentration Kinetics Ultrastructure Microspheres Species Specificity Vero Cells Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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