NDLI: Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium.

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Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium.

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Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Jun-Ping Wang, Qin Xie, Xiao-Ling Li, Xun Wang, Ai-Qin
Description	Author Affiliation: Zhang JP ( Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, People's Republic of China.)
Abstract	Layered double hydroxides (LDHs) are promising materials for the preparation of novel drug delivery matrices. To reveal the interaction between LDHs and polymers, a series of pH-sensitive sodium alginate/layered double hydroxides (SA/LDHs) hybrid beads were prepared using the simple surface crosslinking method. The SA/LDHs hybrid beads were characterized by FTIR, XRD, and SEM to study their structure and the role that LDHs play. Swelling behaviors in various aqueous solutions and drug loading as well as controlled release behavior of the SA/LDHs hybrid beads were also investigated by using diclofenac sodium (DS) as the model drug to reveal the effects of introduced LDHs. The results indicate that the positively charged LDHs layers are adsorbed on the negatively charged SA polymer chains through electrostatic interaction and act as inorganic crosslinkers in the three-dimensional network. In addition, a small part of DS molecules intercalate into layers of LDHs through an anion exchange process. The electrostatic interaction between LDHs and SA has restricted movability of the SA polymer chains, and then slows down swelling and dissolution rates of the SA/LDHs hybrid beads in aqueous solutions. The electrostatic interaction and the intercalation of DS into layers of LDHs have also improved the entrapment efficiency (EE) and controlled release behavior of SA/LDHs hybrid beads for DS.
File Format	HTM / HTML
ISSN	15524973
Issue Number	1
Volume Number	92
e-ISSN	15524981
Journal	Journal of Biomedical Materials Research Part B: Applied Biomaterials
Language	English
Publisher	Wiley
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical engineering Alginates Chemistry Anti-inflammatory Agents, Non-steroidal Administration & Dosage Diclofenac Delayed-action Preparations Glucuronic Acid Hexuronic Acids Hydrogen-ion Concentration Microscopy, Electron, Scanning Spectroscopy, Fourier Transform Infrared X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biomedical Engineering

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