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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Hui Wang, Jun-Qiao Nie, Shao-Ping Wang, Yuan-Xing Cui, Steve W. Xie, Ming-Yong |
| Description | Author Affiliation: Zhang H ( State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China); Wang JQ ( State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China. Electronic address: 815139617@qq.com.); Nie SP ( State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China. Electronic address: spnie@ncu.edu.cn.); Wang YX ( State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China. Electronic address: yuanxingwang@tom.com.); Cui SW ( State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China); Xie MY ( State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China. Electronic address: myxie@ncu.edu.cn.) |
| Abstract | Sulfated modification was carried out to modify a water-insoluble polysaccharide from Ganoderma atrum (AGAP). The effects of sulfation on structure, physicochemical and functional properties of AGAP were investigated. Three sulfated derivatives were prepared, designated as S-1, S-2 and S-3 with degree of substitution (DS) of 0.35, 0.74 and 1.14, respectively. AGAP was elucidated as an -(1â3)-glucan with few branches terminated by single mannose or xylose residues. The molecular weight (Mw) and radius of gyration (Rg) were estimated to be 1665 kDa and 65.49 nm, respectively. After sulfated modification, non-selective sulfation occurred preferably at O-6, partially at O-2 and O-4 positions of the glucosyl residues. The water-solubility of the derivatives was significantly improved in a DS-dependent manner. Mw of the derivatives showed a sharp decrease, and the chain conformation was estimated to be expanded stiff in phosphate buffer. In vitro tests showed that sulfated modification improved its antioxidant activities and anti-proliferative ability against S-180 tumor cells. This study suggested that sulfated modification was an effective approach to improve the water-solubility and functional properties of insoluble polysaccharides. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 79 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Antioxidants Chemistry Cytostatic Agents Fungal Polysaccharides Ganoderma Glucans Sulfates Animals Isolation & Purification Pharmacology Biphenyl Compounds Antagonists & Inhibitors Carbohydrate Conformation Cell Line, Tumor Cell Proliferation Drug Effects Inhibitory Concentration 50 Mice Molecular Weight Picrates Solubility Structure-activity Relationship Water Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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