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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Algul, Derya Sipahi, Hande Aydin, Ahmet Kelleci, Feyza Ozdatli, Sukran Yener, Fatma Gulgun |
| Description | Author Affiliation: Algul D ( Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey); Sipahi H ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey.); Aydin A ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey.); Kelleci F ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Kayisdagi, Istanbul 34755, Turkey.); Ozdatli S ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Medipol University, Beykoz, Istanbul 34810, Turkey.); Yener FG ( Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul 34116, Turkey.) |
| Abstract | Biomimetic three-layered monolithic scaffold (TLS) intended for treatment of osteochondral defects was fabricated by using freeze drying method. The multilayered material was prepared with chitosan (C) and alginate (A) polyelectrolyte complex (CA/PEC) as a cartilaginous layer, a combination of CA/PEC (60 wt%) and ß-tricalcium phosphate (ß-TCP) (40 wt%) as an intermediate layer and a combination of CA/PEC (30 wt%) and ß-TCP (70 wt%) as a subchondral layer in order to mimic the inherent gradient structure of healthy osteochondral tissue. Characterization of the scaffolds was performed using Fourier transform infrared (FT-IR) spectroscopy analysis, swelling and scanning electron microscopy (SEM) tests. In vitro cytotoxicity assay with L929 cells and EpiDerm skin irritation test (SIT) using the EpiDerm reconstructed human epidermal (RHE) model were performed to analyze biocompatibility of the scaffolds. Characterization results showed that there were strong ionic interactions among chitosan, alginate and ß-TCP and the layers showed interconnected porous structure with different swelling ratios. The relative cell viability and SIT results were greater than 70% indicating that the scaffolds are considered nontoxic according to the International Organization for Standardization (ISO) standard. All results taken together, biomimetic TLS can be considered to be suitable for osteochondral applications. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 79 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Alginates Chemistry Biomimetic Materials Pharmacology Calcium Phosphates Chitosan Tissue Scaffolds Animals Bone And Bones Cartilage Cell Line Cell Survival Drug Effects Fibroblasts Cytology Freeze Drying Glucuronic Acid Hexuronic Acids Humans Materials Testing Mice Porosity Tissue Engineering Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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