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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Florczyk, Stephen J. Kim, Dae-Joon Wood, David L. Zhang, Miqin |
| Description | Country affiliation: United States Author Affiliation: Florczyk SJ ( Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195-2120, USA.) |
| Abstract | Fabrication of porous polymeric scaffolds with controlled structure can be challenging. In this study, we investigated the influence of key experimental parameters on the structures and mechanical properties of resultant porous chitosan-alginate (CA) polyelectrolyte complex (PEC) scaffolds, and on proliferation of MG-63 osteoblast-like cells, targeted at bone tissue engineering. We demonstrated that the porous structure is largely affected by the solution viscosity, which can be regulated by the acetic acid and alginate concentrations. We found that the CA PEC solutions with viscosity below 300 Pa.s yielded scaffolds of uniform pore structure and that more neutral pH promoted more complete complexation of chitosan and alginate, yielding stiffer scaffolds. CA PEC scaffolds produced from solutions with viscosities below 300 Pa.s also showed enhanced cell proliferation compared with other samples. By controlling the key experimental parameters identified in this study, CA PEC scaffolds of different structures can be made to suit various tissue engineering applications. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 4 |
| Volume Number | 98 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-09-15 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Viscosity Research Support, Non-u.s. Gov't Cell Proliferation Humans Cytology Materials Testing Alginates Hexuronic Acids Osteoblasts Journal Article Discipline Biomedical Engineering Tissue Scaffolds Chemistry Animals Glucuronic Acid Biocompatible Materials Physiology Chitosan Porosity Polymers Evaluation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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