NDLI: An updated meta-analysis of transforming growth factor-β1 gene: three polymorphisms with gastric cancer

Content Provider	Springer Nature Link
Author	Chang, Wei wei Zhang, Liu Su, Hong Yao, Ying shui
Copyright Year	2013
Abstract	To derive a more precise estimation of the relationship between TGF-β1 polymorphisms and gastric cancer (GC) risk, we conducted a meta-analysis of all available case–control studies relating the C-509 T, T869C, and G 915C polymorphisms of the TGF-β1 gene to the risk of developing GC. The effect summary odds ratio (OR) and 95 % confidence intervals (CIs) were obtained. Funnel plots and Egger's test were used to estimate publication bias. Finally, 11 studies were included in the final meta-analysis. With respect to C-509 T polymorphism, it was found that significantly increased GC risk was associated with the TT genotype in the recessive genetic model in overall analysis (TT vs. CC + CT: OR = 1.23, 95 % CI 1.09–1.38, P $_{heterogeneity}$ = 0.13) and in Asian population (TT vs. CC + CT: OR = 1.24, 95 % CI 1.10–1.39, P $_{heterogeneity}$ = 0.18). With respect to T869C and G915C polymorphisms, no significant association with GC risk was demonstrated in overall analysis and subgroup analyses according to ethnicity for all genetic models. This meta-analysis suggested that the T allele of TGF-β1 509C/T polymorphism is probably the susceptibility factor for GC.
Starting Page	2837
Ending Page	2844
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-20
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Transforming growth factor-β1 Polymorphism GC Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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