NDLI: Abnormal expression of FLOT1 correlates with tumor progression and poor survival in patients with non-small cell lung cancer

Content Provider	Springer Nature Link
Author	Li, Hui Wang, Rui Ming Liu, Shu Guang Zhang, Jian Ping Luo, Jing Yu Zhang, Bai Jiang Zhang, Xing Guo
Copyright Year	2013
Abstract	Recent studies have revealed that flotillin-1 (FLOT1) plays important roles in cancer progression. However, the role of FLOT1 in development and progression of non-small cell lung cancer (NSCLC) remains largely unknown. The objective of the current study was to investigate the expression pattern and clinicopathological significance of FLOT1 in patients with NSCLC. Real-time quantitative polymerase chain reaction was applied to examine FLOT1 mRNA expression in 52 pairs of NSCLC tissues and adjacent noncancerous tissues. Immunohistochemistry was performed to examine FLOT1 protein expression in paraffin-embedded tissues from 106 NSCLC patients. Statistical analyses were applied to evaluate the diagnostic value and associations of FLOT1 expression with clinicopathological characteristics. FLOT1 mRNA expression was evidently upregulated in NSCLC tissues compared with that in the adjacent noncancerous tissues. In the 106 cases of tested NSCLC samples, FLOT1 protein level was positively correlated with tumor size, tumor stage, and lymph node metastasis. Patients with higher FLOT1 expression had shorter overall survival time, whereas those with lower FLOT1 expression had longer survival time. Taken together, our findings indicate that FLOT1 may play an important role in NSCLC tumorigenesis. Further elucidation of the molecular mechanisms underlying the role of FLOT1 is warranted.
Starting Page	3311
Ending Page	3315
Page Count	5
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	FLOT1 NSCLC Prognosis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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