NDLI: Aurora-A: a potential DNA repair modulator

Content Provider	Springer Nature Link
Author	Wang, Yan Sun, Huizhen Wang, Ziliang Liu, Mingming Qi, Zihao Meng, Jiao Sun, Jianmin Yang, Gong
Copyright Year	2013
Abstract	It is well-known that overexpression of Aurora-A promotes tumorigenesis, but the role of Aurora-A in the development of cancer has not been fully investigated. Recent studies indicate that Aurora-A may confer cancer cell chemo- and radioresistance through dysregulation of cell cycle progression and DNA damage response. Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21$^{waf1/cip1}$, and p27$^{cip/kip}$ but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression. Other studies indicate that Aurora-A suppresses BRCA1, BRCA2, RAD51, poly(ADP ribose) polymerase (PARP), and gamma-H2AX to dysregulate DNA damage response. Aurora-A may also interact with RAS and Myc to control DNA repair indirectly. In this review, we summarized the potential role of Aurora-A in DNA repair from the current literatures and concluded that Aurora-A may function as a DNA repair modulator to control cancer cell radio- and chemosensitivity, and that Aurora-A-associated DNA repair molecules may be considered for targeted cancer therapy.
Starting Page	2831
Ending Page	2836
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Aurora-A p53 BRCA1/2 DNA damage repair Radio- and Chemoresistance Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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