NDLI: Gly82Ser polymorphism of the receptor for advanced glycation end-product (RAGE) potential high risk in patients with colorectal cancer

Content Provider	Springer Nature Link
Author	Qian, Fei Sun, Bao lan Zhang, Wen Yi Ke, Jing Zhu, Jianwei
Copyright Year	2013
Abstract	The receptor for advanced glycation end products (RAGE) has previously been suggested to stimulate the growth, survival, and metastatic spread of colorectal cancers (CRC). The genetic variant Gly82Ser of RAGE influences its function and is associated with an increased risk of gastric cancer and multiple sclerosis. To investigate the association between the Gly82Ser polymorphisms of RAGE and the risk of CRC, 90 CRC patients and 78 control subjects with benign polyps were genotyped and the results were analyzed using the SPSS statistical software.In comparing with the control group, the CRC group has a higher ratio in the Gly82Ser polymorphism. The odds ratio (OR) for heterozygous GS is 2.037 (95 % CI 1.207–3.438); the OR for carriers with the S allele (SS) is 3.32 (95 % CI 0.94–11.65). Further stratification analysis of the correlation of the Gly82Ser polymorphism with tumor stages and differentiation indicated that CRC patients with TNM (III + IV) and/or patients with poorly differentiated colorectal cancer have an elevated Gly82Ser polymorphism. The OR for TNM (III + IV) is 3.575, 95 % CI 1.495–8.550, and the OR for poorly differentiated is 3.580, 95 % CI 1.390–9.217. In conclusion, the RAGE gene Gly82Ser polymorphism may confer not only an increased risk of CRC but also an increased invasion of CRC in the Chinese population.
Starting Page	3171
Ending Page	3175
Page Count	5
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-19
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Receptor for advanced glycation end-products (RAGE) Gly82Ser polymorphism Colorectal cancer (CRC) Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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