NDLI: Quantitative assessment of the influence of CYP1B1 polymorphisms and head and neck squamous cell carcinoma risk

Content Provider	Springer Nature Link
Author	Shen, Ming Hu, Yuan Yuan Hu, Yu Kun Xie, Long Chuan Xu, Xiao Ming Wu, Ming Yue Niu, Yu Ming
Copyright Year	2013
Abstract	The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case–control studies were collected; odds ratios (ORs) with 95 % confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95 % CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95 % CI = 1.03–1.25, P = 0.014, P $_{heterogeneity}$ = 0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95 % CI = 1.06–1.60, P = 0.013, P $_{heterogeneity}$ = 0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95 % CI = 1.05–1.46, P = 0.013, P $_{heterogeneity}$ = 0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.
Starting Page	3891
Ending Page	3897
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-12-17
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	CYP1B1 Polymorphism Head and neck squamous cell carcinoma Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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