NDLI: Xeroderma pigmentosum complementation group D (XPD) gene polymorphisms contribute to bladder cancer risk: a meta-analysis

Content Provider	Springer Nature Link
Author	Li, Su Xia Dai, Qiang Sheng Chen, Su Xiu Zhang, Shao Dan Liao, Xiao Yu Deng, Xia Chi, Hong Bo Li, Feng Jie Zhu, Jin Hong Jiang, Yi Yan
Copyright Year	2013
Abstract	Numerous epidemiological studies have been conducted to investigate the association between Xeroderma pigmentosum complementation group D (XPD) Asp312Asn (rs1799793 G > A) and Lys751Gln (rs13181 A > C) polymorphisms and bladder cancer risk; however, the conclusions remain controversial. With this in mind, we performed this meta-analysis with 11 studies including 3,797 cases and 5,094 controls for Asp312Asn and 21 studies including 6,360 cases and 7,894 controls for Lys751Gln polymorphism. We searched available literatures from PubMed, Embase, and CBM databases. Crude odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to assess the strength of the associations. Moreover, to validate biological plausibility of our findings, the effects of these two polymorphisms on XPD gene expression within three ethnicities was determine by gene expression analysis based on imputed genotypes from HapMap. Overall, the variant allele of Asp312Asn polymorphism was associated with an increased risk of bladder cancer (Asn/Asn vs. Asp/Asp: OR = 1.51, 95 % CI = 1.19–1.91; Asp/Asn vs. Asp/Asp: OR = 1.23, 95 % CI = 1.12–1.35; recessive model: OR = 1.33, 95 % CI = 1.10–1.61; dominant model: OR = 1.32, 95 % CI = 1.14–1.52; and allele comparing: OR = 1.26, 95 % CI = 1.11–1.42). We found the Lys751Gln was associated with increased bladder cancer risk only under the recessive model (OR = 1.14, 95 % CI = 1.01–1.29). Stratification analyses demonstrated an increased risk for Asians and hospital-based studies under all genetic models while only under the dominant model for Caucasians as to the Asp312Asn polymorphism and for Caucasians under the recessive model as to the Lys751Gln polymorphism. We also found the Asp312Asn polymorphism can significantly influence mRNA expression levels among Asians and Caucasians, and the Lys751Gln polymorphism has a similar effect for Caucasians. Despite some limitations, this meta-analysis suggests that polymorphisms in XPD gene may contribute to bladder cancer susceptibility. These findings need further validation by large well-designed prospective studies.
Starting Page	3905
Ending Page	3915
Page Count	11
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	4
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-12-18
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Bladder cancer XPD Polymorphism Susceptibility Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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