NDLI: Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population

Content Provider	Springer Nature Link
Author	Zhang, Yan Hong Xu, Qing Zhao, Zhenhong Wu, Junjie Liu, Wei Xing Wang, Hui Jin, Li Wang, Jiu Cun
Copyright Year	2013
Abstract	Polymorphism rs7214723 was reported to be associated with lung cancer risk in UK Caucasians and caused the E375G substitution of CAMKK1 which plays important role in the calcium/calmodulin-dependent kinase cascade. To analyze rs7214723 in CAMKK1 and lung cancer risk in a Chinese population, SNPscan$^{TM}$ was used to genotype polymorphism rs7214723 in 961 lung cancer cases and 999 control subjects. The frequencies of the TT, TC, and CC genotypes of CAMKK1 rs7214723 were 43.3, 42.6, and 14.0 % in controls, and 41.1, 48.0, and 10.9 % in cases, respectively (P = 0.025). Compared with the CC genotype, TC genotype was associated with increased risk of lung cancer (OR 1.500, 95 % CI 1.112–2.022) after adjustment for age, gender, smoking status, and family history. The T allele of rs7214723 is the risk allele for lung carcinogenesis in dominant model (OR 1.354, 95 % CI 1.020–1.797). In stratified analysis, the risk effect of the TC genotype of rs7214723 was more evident in subgroups of those who had never been smokers (OR 1.556, 95 % CI 1.074–2.254). For the population without a family history of cancer, both the TT (OR 1.488, 95 % CI 1.050–2.109) and TC (OR 1.668, 95 % CI 1.180–2.357) carrier had an increased lung cancer risk. E375 is located in the kinase domain of CAMKK1, and E375G may change the electrical charge at the surface and decrease the kinase activity. Polymorphism rs7214723 in CAMKK1 might contribute to the risk of lung cancer in Chinese populations. The T allele is a risk allele in lung carcinogenesis.
Starting Page	3147
Ending Page	3152
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-06-05
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lung cancer CAMKK1 Functional polymorphism Predisposition Association study Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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