NDLI: Association between the XRCC3 C241T polymorphism and lung cancer risk in the Asian population

Content Provider	Springer Nature Link
Author	Tian, Xin Tian, Ye Ma, Ping Sui, Chengguang Meng, Fandong Li, Yan Fu, Liye Jiang, Tao Wang, Yang Jiang, Youhong
Copyright Year	2013
Abstract	X-ray repair cross-complementing group 3 (XRCC3) plays a vital role in maintaining the stability of genome by homologous recombination repair for DNA double-strand breaks. The genetic polymorphism of XRCC3 C241T has been implicated in lung cancer risk, but the findings across published studies in Asians are inconsistent and inconclusive. To estimate the precise association of XRCC3 C241T polymorphism with lung cancer risk, a meta-analysis of all currently available studies in Asians was performed. A comprehensive search of the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases was conducted for eligible studies based on the inclusion criteria. The pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were calculated to assess the association. Besides, subgroup analysis and sensitivity analysis were also performed for further estimation. Seven available studies with a total of 7,398 subjects were finally included into this meta-analysis. The overall ORs indicated that the XRCC3 C241T polymorphism was not associated with a lung cancer risk among Asians in all genetic contrast modes (OR$_{T allele vs. C allele}$ = 1.08, 95 % CI 0.95–1.24, P $_{OR}$ = 0.252; OR$_{TT vs. CC}$ = 1.30, 95 % CI 0.69–2.45, P $_{OR}$ = 0.426; OR$_{CT vs. CC}$ = 1.07, 95 % CI 0.93–1.24, P $_{OR}$ = 0.363; OR$_{TT + CT vs. CC}$ = 1.08, 95 % CI 0.94–1.24, P $_{OR}$ = 0.300; OR$_{TT vs. CC + CT}$ = 1.29, 95 % CI 0.68–2.43, P $_{OR}$ = 0.439). We failed to identify significant association between the XRCC3 C241T polymorphism and risk of lung cancer in Chinese and population-based studies. Interestingly, the pooled ORs in hospital-based studies indicated that the XRCC3 C241T variant carriers were more susceptible to lung cancer (OR$_{T allele vs. C allele}$ = 1.27, 95 % CI 1.04–1.56, P $_{OR}$ = 0.019; OR$_{CT vs. CC}$ = 1.26, 95 % CI 1.01–1.57, P $_{OR}$ = 0.045; OR$_{TT + CT vs. CC}$ = 1.28, 95 % CI 1.03–1.59, P $_{OR}$ = 0.027). Sensitivity analysis confirmed the stability and liability of all results. This meta-analysis suggests that the XRCC3 C241T polymorphism may not exert a risk effect on the lung cancer risk in Asians, although a statistically significant association was observed among the hospital-based studies. Thus, the precise relationship between the XRCC3 C241T variant and lung cancer risk needs further confirmation in future studies with large available data.
Starting Page	2589
Ending Page	2597
Page Count	9
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-06-08
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lung cancer Polymorphism X-ray repair cross-complementing group 3 Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in