NDLI: Glutathione S-transferase M1 null genotype is associated with increased risk of oral cancer in East Asians: a meta-analysis

Content Provider	Springer Nature Link
Author	Zhang, Yi Yu, Qingqing Yu, Weixian Hu, Min
Copyright Year	2013
Abstract	The association between glutathione S-transferase M1 (GSTM1) null genotype and risk of oral cancer in East Asians is uncertain owing to the inconclusive results from published studies. In the present study, we performed a meta-analysis of 12 studies from three East Asian countries (China, Japan, and Korea). Those 12 studies consisted of 1,718 cases and 2,236 controls. The pooled odds ratio (OR) and corresponding 95 % confidence interval (95 %CI) were calculated to assess the relationship. Overall, the meta-analysis showed that GSTM1 null genotype was associated with increased risk of oral cancer in East Asians (OR = 1.48, 95 %CI = 1.09–2.00, P = 0.011). The results of the cumulative meta-analysis further identified the significant association above. Subgroup analysis by countries showed that the association was still significant in Japan (OR = 1.56, 95 %CI = 1.10–2.22, P = 0.012), but not in China (OR = 1.35, 95 %CI = 0.68–2.68, P = 0.393) and Korea (OR = 1.35, 95 %CI = 0.79–2.32, P = 0.271). In conclusion, the meta-analysis suggests that GSTM1 null genotype is associated with increased risk of oral cancer in East Asians. Further studies are needed to provide new and comprehensive assessments on the association in China and Korea.
Starting Page	3183
Ending Page	3188
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-06-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Glutathione S-transferase M1 Oral cancer Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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