NDLI: Comprehensive assessment of the association between DNA repair gene XRCC3 rs861539 C/T polymorphism and lung cancer risk

Content Provider	Springer Nature Link
Author	Ding, Gang Xu, Weiguo Hua, Hongwei Huang, Qian Liang, Hongxiang Ni, Yufeng Ding, Zhaoheng
Copyright Year	2013
Abstract	A few case–control studies were performed to assess the association between X-ray repair cross-complementing group 3 (XRCC3) rs861539 C/T polymorphism and lung cancer susceptibility, but no consistent finding was reported. In the present study, we performed a meta-analysis of 14 case–control studies with a total of 7,869 lung cancer cases and 10,778 controls to provide a comprehensive assessment of the association between XRCC3 rs861539 C/T polymorphism and lung cancer risk. Pooled odds ratios (ORs) and corresponding 95 % confidence intervals (95 % CIs) were calculated to assess the strength of the association. Overall, there was no significant association between XRCC3 rs861539 C/T polymorphism and lung cancer risk under all genetic models [OR (95 % CI) for T versus C, 1.00 (0.89–1.13), P = 0.99; OR (95 % CI) for TT versus CC, 1.07 (0.81–1.41), P = 0.62; OR (95 % CI) for TT/CT versus CC, 0.95 (0.84–1.07), P = 0.39; OR (95 % CI) for TT versus CT/CC, 1.10 (0.86–1.39), P = 0.62]. In the subgroup analyses of both Asians and Caucasians, there was still no significant association between XRCC3 rs861539 C/T polymorphism and lung cancer risk under all genetic models (All P values were more than 0.05). However, there was an obvious association between XRCC3 rs861539 C/T polymorphism and decreased risk of lung cancer in the subgroup analysis of the mixed population (All P values were less than 0.05). In addition, there was some risk of publication bias in the meta-analysis, and there was obvious discrepancy in the findings between studies with large sample size and studies with small sample size in the meta-analysis. The meta-analysis indicates that the association between XRCC3 rs861539 C/T polymorphism and lung cancer risk is still uncertain owing to the obvious discrepancy in the findings between studies with large sample size and studies with small sample size. More studies with large sample size are needed to further assess the association.
Starting Page	2521
Ending Page	2527
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-08-28
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lung cancer XRCC3 Association Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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