NDLI: Association between insulin receptor substrate 1 Gly972Arg polymorphism and cancer risk

Content Provider	Springer Nature Link
Author	Zhang, Hongtuan Wang, Andi Ma, Hui Xu, Yong
Copyright Year	2013
Abstract	Epidemiological studies investigating the association between the insulin receptor substrate 1 (IRS1) gene Gly972Arg (rs1801278) polymorphism and various carcinomas risk reported conflicting results. Thus, a systemic review and meta-analysis of published studies were performed to assess the possible association. A comprehensive search was conducted to identify all eligible studies of IRS1 Gly972Arg polymorphism and cancer risk. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. A total of 16 independent studies, including 11,776 cases and 11,654 controls, were identified. When all studies were pooled, we found a significant association between IRS1 Gly972Arg polymorphism and increased cancer risk under dominant model (OR = 1.16, 95 %CI = 1.04–1.30, P = 0.007) and allelic model (OR = 1.16, 95 %CI = 1.02–1.30, P = 0.02). In subgroup analysis based on cancer type, increased cancer risk was found in ovarian cancer (dominant: OR = 1.55, 95 %CI = 1.17–2.05, P = 0.002; allelic: OR = 1.55, 95 %CI = 1.19–2.01, P = 0.001), breast cancer (allelic: OR = 1.12, 95 %CI = 1.00–1.26, P = 0.05), and other cancers (allelic: OR = 1.31, 95 %CI = 1.00–1.71, P = 0.05). When stratified by study types, significant associations were observed in both cohort studies (dominant: OR = 1.25, 95 %CI = 1.06–1.47, P = 0.007; allelic: OR = 1.25, 95 %CI = 1.07–1.46, P = 0.005) and case–control studies (dominant: OR = 1.15, 95 %CI = 1.01–1.31, P = 0.04). In the subgroup analyses by ethnicity, significantly increased cancer risk was suggested among both Caucasians (dominant: OR = 1.13, 95 %CI = 1.02–1.26, P = 0.02; allelic: OR = 1.13, 95 %CI = 1.03–1.25, P = 0.01) and mixed population (dominant: OR = 1.22, 95 %CI = 1.01–1.46, P = 0.04). Our investigations demonstrate that IRS1 Gly972Arg polymorphism was associated with an increased risk of cancer, and additional well-designed studies are warranted to validate these findings.
Starting Page	2929
Ending Page	2936
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-25
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Insulin receptor substrate 1 Polymorphism Cancer Meta-analysis Association Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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