NDLI: GSTM1 and GSTT1 polymorphism and susceptibility to esophageal cancer in high- and low-risk regions of India

Content Provider	Springer Nature Link
Author	Sharma, Anita Das, Bhudev Chander Sehgal, Ashok Mehrotra, Ravi Kar, Premashish Sardana, Sarita Phukan, Rup Mahanta, Jagdish Purkayastha, Joydeep Saxena, Sunita Kapur, Sujala Chatterjee, Indranil Sharma, Joginder Kumar
Copyright Year	2013
Abstract	Glutathione transferases, a super family of dimeric phase II metabolic enzymes play a vital role in biotransformation of many substances. This study evaluates the influence of genetic polymorphism of GSTM1 and GSTT1 gene loci on esophageal cancer risk in Assam and Delhi from India. DNA from blood samples of esophageal cancer cases (203,112) and controls (286,150) from Assam and Delhi, respectively, were extracted. GSTM1 and GSTT1 polymorphisms were analyzed by multiplex PCR procedure. Differences in proportions were tested using Pearson’s chi-square test with odds ratio (OR) and 95 % confidence interval (CI). Risk of esophageal cancer was approximately twice in individuals having homozygous GSTM1 (OR-2.1, 95 % CI, 1.44–3.13) and GSTT1 null genotypes (OR-1.7,95 % CI, 0.99–2.77) in Assam, and around three times in GSTT1 null genotype (OR-2.9, 95 % CI, 1.56–5.27) in Delhi population. GSTM1 null genotype seems to play a protective role (OR-0.7, 95 % CI, 0.39–1.27) in Delhi. A significant association of GSTM1 null genotype with esophageal cancer was observed in a younger age group in Assam (OR-2.7, 95 % CI, 1.48–5.01), and in Delhi population association was observed in smokers with GSTT1 null genotype (OR-2.5, 95 % CI, 1.04–6.07), and alcoholics having GSTM1 null genotype (OR-2.6, 95 % CI, 0.99–6.77). Significant association of GSTM1 null genotype in Assam was observed between cancer cases and controls in fermented betel nut chewers only (OR-2.8, 95 % CI, 1.19–6.72), whereas, smoking and alcohol failed to show any correlation with GSTM1/GSTT1 genotypes. Cancer development is not only due to exogenous or endogenous carcinogens but depends on their interaction with genes that are involved in the detoxification of these carcinogens.
Starting Page	3249
Ending Page	3257
Page Count	9
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-06-08
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Glutathione transferase Polymorphism GSTM1 GSTT1 Esophageal cancer Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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