NDLI: Association between cytochrome P450 1A1 MspI polymorphism and endometrial cancer risk: a meta-analysis

Content Provider	Springer Nature Link
Author	Han, Linxiao Liu, Yanyan Cao, Weiwei Yuan, Xiuying Li, Cuifeng
Copyright Year	2013
Abstract	Many studies proposed that cytochrome P450 1A1 (CYP1A1) MspI polymorphism may be associated with endometrial cancer risk, but the findings from previous studies reported conflicting results. A meta-analysis of all relevant studies was performed to get a comprehensive assessment of the association between CYP1A1 MspI polymorphism and endometrial cancer risk. Eligible studies were searched in PubMed and China National Knowledge Infrastructure databases. The pooled odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the association. Twelve studies with a total of 2,111 cases and 2,894 controls were finally included into the meta-analysis. Overall, meta-analysis of a total of 12 studies showed that there was no obvious association between CYP1A1 MspI polymorphism and endometrial cancer risk (OR$_{C vs. T}$ = 0.97, 95 % CI 0.77–1.22, P $_{OR}$ = 0.808; OR$_{CC vs. TT}$ = 1.00, 95 % CI 0.57–1.76, P $_{OR}$ = 0.994; OR$_{CC vs. TT/TC}$ = 0.88, 95 % CI 0.65–1.20, P $_{OR}$ = 0.425; OR$_{CC/TC vs. TT}$ = 0.98, 95 % CI 0.74–1.29, P $_{OR}$ = 0.861). Subgroup analyses by ethnicity further showed that there was no obvious association between CYP1A1 MspI polymorphism and endometrial cancer risk in both Caucasians and Asians. There was no obvious risk of publication bias. Therefore, the meta-analysis suggests that CYP1A1 MspI polymorphism is not associated with endometrial cancer risk.
Starting Page	2545
Ending Page	2550
Page Count	6
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-08-07
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Endometrial cancer CYP1A1 MspI Polymorphisms Meta-analysis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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