NDLI: CYP2A6 deletion polymorphism is associated with decreased susceptibility of lung cancer in Asian smokers: a meta-analysis

Content Provider	Springer Nature Link
Author	Liu, Yu liang Xu, Yu Li, Fan Chen, Hong Guo, Shu liang
Copyright Year	2013
Abstract	Cytochrome P450 2A6 (CYP2A6) is an enzyme involved in the metabolism of some tobacco carcinogens, which is an important risk factor of lung cancer. Among CYP2A6 allelic variants, CYP2A64 presents a whole gene deletion that accounts for the majority of poor metabolizer. In this study, a meta-analysis was performed to assess the association between CYP2A64 and risk of lung cancer. Literature searches were conducted to identify peer-reviewed manuscripts published up to December 20, 2012. Pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated in a fixed-effects model and a random-effects model when appropriate. Eight eligible studies with 3,203 lung cancer cases and 2,839 controls were included in this study. Overall, no significant association was observed in CYP2A64 with the risk of lung cancer under any genetic model for all samples after correction. However, subgroup analysis showed that significant associations were observed in Asian with pooled OR (95 %CI) of 0.761 (0.672–0.861) for allele comparison, 0.769 (0.668–0.886) for dominant model, and 0.522 (0.359–0.760) for recessive model. Furthermore, after stratifying Asian samples according to smoking status, significant associations were only observed in smokers with pooled OR (95 %CI) of 0.713 (0.607–0.838) for allele comparison, 0.720 (0.596–0.869) for dominant model, and 0.444 (0.275–0.715) for recessive model. This meta-analysis suggests that the CYP2A64 polymorphism was associated with susceptibility of lung cancer for smokers in Asian. The whole gene deletion of CYP2A6 might decrease the risk of tobacco-related lung cancer in Asian.
Starting Page	2651
Ending Page	2657
Page Count	7
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	34
Issue Number	5
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-07
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lung cancer CYP2A6*4 Cytochrome P450 2A6 CYP2A6 deletion Meta-analysis Smoker Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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