NDLI: Exploratory investigation of plasma metabolomics in human lung adenocarcinoma

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Exploratory investigation of plasma metabolomics in human lung adenocarcinoma

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Molecular BioSystems Vol - 9 Issue - 8

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Exploratory investigation of plasma metabolomics in human lung adenocarcinoma

Content Provider	Royal Society of Chemistry (RSC)
Author	Tan, Chuen Seng Toh, Wei Zhong Wen, Tao Ong, Choon Nam Wen, Zongmei Wu, Chunyan Gao, Liang
Copyright Year	2013
Abstract	Globally lung cancer is common among males and recently also noted with increasing incidences in females, especially adenocarcinoma. Further, most lung cancers are not easily detected until the late stage. Metabolic profiling of plasma low molecular weight metabolites may help unveil the complex pathophysiological changes during early lung adenocarcinoma development. Here we used a combination of gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) methods to investigate the metabolic signatures in the plasma of 31 stage I human lung adenocarcinoma patients and 28 healthy controls. The metabolic profiles were assayed using orthogonal projections to latent structures discriminant analysis (OPLS-DA), and were further analyzed to identify the associated marker metabolites. The OPLS-DA models derived from both GC-MS and LC-MS showed significant discriminations in metabolic profiles between cases and healthy controls. It was found that around 37 metabolites contributed to the differences. The alterations of these metabolites implied disturbances in amino acids, lipids, fatty acids and glutaminolysis metabolism in human lung adenocarcinoma, even after removal of influencing factors such as age, gender and smoking habits. Of particular interest, the sex hormone metabolic pathway involving the sulfate conjugate of testosterone, androsterone and pregnenolone was found to be disturbed considerably. All these metabolic perturbations occur at an early stage of lung adenocarcinoma and thus could act as biomarkers for its early diagnosis. These exploratory findings suggest that integration of two sensitive and complementary metabolomic approaches enables a comprehensive metabolite profiling for human lung adenocarcinoma, although a more extensive study is needed to confirm the findings.
Starting Page	2370
Ending Page	2378
Page Count	9
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	9
Issue Number	9
Journal	Molecular BioSystems
DOI	10.1039/c3mb70138g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Adenocarcinoma Hormone Gas chromatography\u2013mass spectrometry Metabolomics Metabolite Lung cancer Lung Tobacco smoking Metabolic pathway Androsterone Orthogonality Metabolism Pregnenolone Blood plasma Testosterone Liquid chromatography\u2013mass spectrometry Linear discriminant analysis Sulfate
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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