NDLI: <i>Salacia chinensis</i> L. extract ameliorates abnormal glucose metabolism and improves the bone strength and accumulation of AGEs in type 1 diabetic rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Oikawa, Norihisa Yamanaka, Mikihiro Ohno, Rei-ichi Kobayashi, Masakazu Shinagawa, Masatoshi Sugawa, Hikari Hatano, Kota Tagawa, Tomoya Shirakawa, Jun-ichi Nagai, Mime Gotoh, Kentaroh Nagai, Ryoji Furusawa, Chisato Masuda, Shuichi Kinoshita, Sho Ichimaru, Kenta Arakawa, Shoutaro
Copyright Year	2016
Abstract	Although extracts of the roots and stems of Salacia chinensis have been used in folk medicines for chronic diseases such as rheumatism, irregular menstruation, asthma and diabetes mellitus, little is known about the mechanism by which Salacia chinensis extract (SCE) ameliorates these diseases. To clarify whether SCE ameliorates the progression of lifestyle-related diseases, the inhibitory effect of SCE on the formation of advanced glycation end products (AGEs) was analyzed in a rat model of streptozotocin-induced diabetes. Although the oral administration of SCE did not ameliorate the diabetes-induced decrease in body weight, it ameliorated the increase in glycoalbumin levels in diabetic rats. An analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) demonstrated that the levels of Nε-(carboxymethyl)lysine (CML) were highest in the femurs and that they increased by the induction of diabetes. The administration of SCE also ameliorated the decreased femur strength and the accumulation of CML. Furthermore, when all of the carbohydrates in the chow of diabetic rats were replaced with free glucose, the administration of SCE significantly ameliorated a diabetes-induced increase in glycoalbumin and decrease in serum creatinine level and body weight. This study provides evidence to support that SCE ameliorates diabetes-induced abnormalities by improving the uptake of glucose by various organs.
Starting Page	2508
Ending Page	2515
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	6
Journal	Food & Function
DOI	10.1039/c5fo01618e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	SCE CML Salacia 120347 Salacia Rheumatism Irregular menstruation Asthma Diabetes mellitus Glycation High-performance liquid chromatography Mass spectrometry Lysine Femur Glucose Creatinine
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Dietary intake increases serum levels of carboxymethil-lysine (CML) in diabetic patients

Salacia chinensis extract (SCE) modulates carbohydrates and lipid metabolism: in vitro and in vivo models

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