NDLI: Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Bao, Lei Cai, Xiaxia Wang, Nan Ren, Jinwei Mao, Ruixue Xu, Meihong Li, Yong Li, Di Chen, Qihe
Copyright Year	2016
Abstract	Nucleotides have been reported to be effective in attenuating liver damage and regulating gut microbiota. However, the protective effect of nucleotides against alcoholic liver injury remains unknown. The present study aims to investigate whether nucleotides ameliorate alcoholic liver injury and explores the possible mechanism. Male Wistar rats were given alcohol, equivalent distilled water or an isocaloric amount of dextrose intragastrically twice daily for up to 6 weeks respectively. Two subgroups of alcohol-treated rats were fed with a nucleotide-supplemented AIN-93G rodent diet. Serum enzymes, inflammatory cytokines and microbiota composition of the caecum content were evaluated. We found that nucleotides could significantly decrease serum alanine aminotransferase and aspartate aminotransferase, plasma lipopolysaccharide and inflammatory cytokine levels. Sequencing of 16S rRNA genes revealed that nucleotide-treated rats showed a higher abundance of Firmicutes and a lower abundance of Bacteroidetes than alcohol-treated rats. Moreover, nucleotide treatment inhibited the protein expression of toll-like receptor 4, CD14 and repressed the phosphorylation of inhibitor kappa Bα and nuclear factor-κB p65 in the liver. These results suggested that nucleotides suppressed the inflammatory response and regulated gut microbiota in alcoholic liver injury. The partial inhibition of lipopolysaccharide – toll-like receptor 4-nuclear factor-κB p65 signaling in the liver may be attributed to this mechanism.
Starting Page	2898
Ending Page	2908
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	6
Journal	Food & Function
DOI	10.1039/c5fo01580d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Bacteroidetes Liver Microbiota Glucose Rodent Cecum Alanine transaminase Aspartate transaminase Blood plasma Lipopolysaccharide Cytokine 16S ribosomal RNA Firmicutes Nucleotide Protein Toll-like receptor CD14 Phosphorylation Enzyme inhibitor NF-κB
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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