NDLI: Myricetin ameliorates brain injury and neurological deficits <i>via</i> Nrf2 activation after experimental stroke in middle-aged rats

Please wait, while we are loading the content...

Salacia chinensis L. extract ameliorates abnormal glucose metabolism and improves the bone strength and accumulation of AGEs in type 1 diabetic rats

Acrylamide mitigation strategies: critical appraisal of the FoodDrinkEurope toolbox

Methionine sulfoxide profiling of milk proteins to assess the influence of lipids on protein oxidation in milk

1,25-Dihydroxyvitamin D increases the gene expression of enzymes protecting from glucolipotoxicity in peripheral blood mononuclear cells and human primary endothelial cells

Investigations on the reactions of α-dicarbonyl compounds with amino acids and proteins during in vitro digestion of biscuits

Formation scheme and antioxidant activity of a novel Maillard pigment, pyrrolothiazolate, formed from cysteine and glucose

The anti-inflammatory effect of a glycosylation product derived from the high hydrostatic pressure enzymatic hydrolysate of a flatfish byproduct

Eucommia ulmoides extracts prevent the formation of advanced glycation end products

Effects of odor generated from the glycine/glucose Maillard reaction on human mood and brainwaves

Antioxidant properties of formula derived Maillard reaction products in colons of intrauterine growth restricted pigs

Encapsulation of ascorbic acid promotes the reduction of Maillard reaction products in UHT milk

Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy?

Zebrafish dives into food research: effectiveness assessment of bioactive compounds

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

A novel multi-biofunctional protein from brown rice hydrolysed by endo/endo-exoproteases

Vegetable dietary fibres made with minimal processing improve health-related faecal parameters in a valid rat model

Atomic force microscopy-guided fractionation reveals the influence of cranberry phytochemicals on adhesion of Escherichia coli

Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea

Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat diet

Digestion of cooked meat proteins is slightly affected by age as assessed using the dynamic gastrointestinal TIM model and mass spectrometry

Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9–39) in a normoglycemic mouse model

In vitro assessment of potential intestinal absorption of some phenolic families and carboxylic acids from commercial instant coffee samples

Food-grade Pickering emulsions stabilised with solid lipid particles

Extruded whole grain diets based on brown, soaked and germinated rice. Effects on cecum health, calcium absorption and bone parameters of growing Wistar rats. Part I

Extruded whole grain diets based on brown, soaked and germinated rice. Effects on the lipid profile and antioxidant status of growing Wistar rats. Part II

The impact of cooking methods on the nutritional quality and safety of chicken breaded nuggets

Rice bran proteins and their hydrolysates modulate cholesterol metabolism in mice on hypercholesterolemic diets

Enzymatic synthesis, structural characterization and antioxidant capacity assessment of a new lipophilic malvidin-3-glucoside–oleic acid conjugate

Structural characterization and immunomodulatory activity of Grifola frondosa polysaccharide via toll-like receptor 4–mitogen-activated protein kinases–nuclear factor κB pathways

Sea cucumber peptides exert anti-inflammatory activity through suppressing NF-κB and MAPK and inducing HO-1 in RAW264.7 macrophages

The effect of the olive fruit fly (Bactrocera oleae) on quality parameters, and antioxidant and antibacterial activities of olive oil

Intestinal immunomodulating activity and structural characterization of a new polysaccharide from stems of Dendrobium officinale

Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells

The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice

A method for assessing real time rates of dissolution and absorption of carbohydrate and other food matrices in human subjects

Consumption of dairy yogurt with the polysaccharide rhamnogalacturonan from the peel of the Korean citrus hallabong enhances immune function and attenuates the inflammatory response

Active Lactobacillus rhamnosus LA68 or Lactobacillus plantarum WCFS1 administration positively influences liver fatty acid composition in mice on a HFD regime

The inhibitory kinetics and mechanism of dietary vitamins D₃ and B₂ on xanthine oxidase

Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats

Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba

Porcine myofibrillar proteins as potential precursors of bioactive peptides – an in silico study

A novel polysaccharide isolated from mulberry fruits (Murus alba L.) and its selenide derivative: structural characterization and biological activities

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

Correction: Microencapsulation of probiotics in hydrogel particles: enhancing Lactococcus lactis subsp. cremoris LM0230 viability using calcium alginate beads

Back cover

Food & Function Vol - 7 Issue - 5

Food & Function Vol - 7 Issue - 4

Food & Function Vol - 7 Issue - 3

Food & Function Vol - 7 Issue - 2

Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Cao, Xiaoqin Zhang, Lu Ding, Hong Peng, Anlin Wu, Shuangchan Xiang, Jin Yue, Yuan Yin, Shanye
Copyright Year	2016
Abstract	The aim of our study was to investigate the protective effects and underlying mechanisms of myricetin, a bioactive food compound, on brain injury and neurological deficits after ischemic stroke. Treatment of myricetin significantly attenuated oxygen–glucose deprivation (OGD)-induced cell death in SHSY5Y cells in vitro. In a rat model of cerebral ischemia, myricetin was administered intragastrically at 2 h before and every day after middle cerebral artery occlusion (MCAO). The effects of myricetin were evaluated by various biochemical assays and neurobehavioral tests. Treatment with myricetin resulted in decreased infarction volume, reduced neuronal loss as well as lessened production of reactive oxygen species (ROS) and malondialdehyde following MCAO. We also found evidence that myricetin treatment could enhance the activity of antioxidant enzymes and mitochondrial function. Meanwhile, myricetin treatment reversed the suppression of Nrf2 nuclear translocation, and increased HO-1 expression in the ipsilateral ischemic brain and in the normal brain. Moreover, our results suggested that myricetin treatment resulted in significant improvement in neurological function. In conclusion, treatment with myricetin attenuates brain injury and neurological deficits in a rat model of cerebral ischemia via improvement of mitochondrial function and activation of the Nrf2 pathway.
Starting Page	2624
Ending Page	2634
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	6
Journal	Food & Function
DOI	10.1039/c6fo00419a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	OGD MCAO Stroke SH-SY5Y Brain ischemia Middle cerebral artery Infarction Reactive oxygen species Malondialdehyde Antioxidant NFE2L2 HMOX1 Ischemia
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dexmedetomidine ameliorates ischemia-induced nerve injury by up-regulating Sox11 expression.

Critical Role of Nrf2 in Experimental Ischemic Stroke

Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway

Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy

The Interleukin-8 (IL-8/CXCL8) Receptor Inhibitor Reparixin Improves Neurological Deficits and Reduces Long-term Inflammation in Permanent and Transient Cerebral Ischemia in Rats

Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.

Effect of Rosiglitazone, on infarct volume and neurological deficits in local brain ischaemia

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

Similar Documents

Dexmedetomidine ameliorates ischemia-induced nerve injury by up-regulating Sox11 expression.

Critical Role of Nrf2 in Experimental Ischemic Stroke

Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway

Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy

The Interleukin-8 (IL-8/CXCL8) Receptor Inhibitor Reparixin Improves Neurological Deficits and Reduces Long-term Inflammation in Permanent and Transient Cerebral Ischemia in Rats

Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.

Effect of Rosiglitazone, on infarct volume and neurological deficits in local brain ischaemia

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats