NDLI: Antioxidant properties of formula derived Maillard reaction products in colons of intrauterine growth restricted pigs

Content Provider	Royal Society of Chemistry (RSC)
Author	Hamoudi, Dounia Reygnier, Julie Bahi-Jaber, Narges Firmin, Stéphane Larcher, Thibaut Abdennebi-Najar, Latifa Dou, Samir Elmhiri, Ghada
Copyright Year	2016
Abstract	Objective: the present study has been conducted to evaluate the impact of the consumption of high MRP formula on changes in the microbiota and the oxidative status, during development, in the colons of intrauterine growth restricted (IUGR) juvenile pigs. Methods: over a 3-week period, fifteen-day old piglets received formula with two different heat treatments. A formula heated at high temperature (HHF, n = 8) and another one heated at a low temperature (LHF, n = 8). After weaning, animals were fed, ad libitum, a solid diet until postnatal day 54 (PND54). The diversity and composition of the major microbiota were analyzed by CE SSCP and qPCR at postnatal day 36 (PND36) and PND54. Protein oxidation levels, glutathione peroxidase (GPX) activity, catalase (CAT), manganese dependent superoxide dismutase (Mn SOD), NFκB and inducible nitric oxide synthase (iNOS) gene expression were measured in the colon at the juvenile stage (PND54). Results: HHF resulted in a significant decrease in bacterial diversity in the colon at PND36. An increase in the total count of Bifidobacteria, Lactobacillus, Bacteroidetes and Enterobacteria, without major changes in total microbiota was evidenced by qPCR, suggesting qualitative changes in the bacterial population of the HHF group. The imbalance of microbiota observed at PND36 was significantly modified at PND54, when animals received a solid diet. Colon GPX activity (p < 0.05) and gene expression of CAT and iNOS were significantly (p < 0.05) upregulated in the HHF group. No differences in the total protein oxidation and carbonyl score were found in the HHF group. Colon redox enzyme gene expression and pro-inflammatory factor NFκB negatively correlated (p < 0.05) with the bacterial population, suggesting the involvement of certain phyla in controlling the oxidative status of the IUGR piglets, fed on the high AGE formula. Conclusion: during development, consuming a high load MRP formula was associated with a major modification in the diversity and composition of the microbiota. The onset of an IUGR adaptive oxidant defense mechanism was found to counteract the oxidative stress induced by the presence of MRPs in formula.
Starting Page	2582
Ending Page	2590
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	6
Journal	Food & Function
DOI	10.1039/c5fo01551k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MRP Lactobacillus Bacteroidetes Enterobacteria Microbiota Ad libitum Glutathione peroxidase Catalase Manganese Superoxide dismutase NF-κB Nitric oxide synthase Gene Large intestine Bifidobacterium Protein Carbonyl group Redox Enzyme Phylum The Onset Oxidative stress
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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