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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Kim, Minjoo Kim, Minkyung Kwak, Jung Hyun Lee, Jong Ho Chang, Dong Hoon Lee, Sang-Hyun Yu, Won Kyu Lee, Mi-Hyang |
| Copyright Year | 2016 |
| Abstract | The aim of this study was to investigate the impact of consuming dairy yogurt supplemented with rhamnogalacturonan (RG), a polysaccharide from the peel of the Korean citrus hallabong, on natural killer (NK) cell activity and circulating cytokine levels. A randomized, double-blind, placebo-controlled study was conducted on 120 nondiabetic and nonobese subjects. Over an eight-week period, the test group consumed one pack (150 mL) of dairy yogurt containing 50 mg of probiotics and 100 mg of hallabong peel polysaccharide (60% RG) each day, whereas the placebo group consumed the same product without the hallabong peel supplement. NK cell activity (%) was measured based on the ratios of the effector cells (E; peripheral blood mononuclear cells, PBMCs) from each participant relative to the target cells (T; K562 cells) at E : T ratios of 10 : 1, 5 : 1, 2.5 : 1, or 1.25 : 1. NK cell activities under all assay conditions and interleukin (IL)-12 and interferon (IFN)-γ levels were significantly increased in the test group at eight weeks compared to the baseline values, whereas the placebo group showed a significant increase only in NK cell activity at E : T = 1.25 : 1. The test group had significantly greater increases in the changes in serum NK cell activity at the E : T ratios of 10 : 1, 5 : 1, and 2.5 : 1 and in the increases in IL-12 and IFN-γ levels than were observed in the placebo group, after adjusting for baseline values. After eight weeks of treatment, significant reductions were found in IL-6 and IL-1β levels in both the placebo and test groups. The daily consumption of dairy yogurt supplemented with RG, a polysaccharide from the peel of the Korean citrus hallabong, enhanced NK cell function and attenuated pro-inflammatory cytokine levels (ClinicalTrials.gov: NCT02535663). |
| Starting Page | 2833 |
| Ending Page | 2839 |
| Page Count | 7 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 7 |
| Issue Number | 6 |
| Journal | Food & Function |
| DOI | 10.1039/c5fo01103e |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | NK Yogurt Pectin Polysaccharide Citrus Dekopon Natural killer cell Cytokine Placebo K562 cells Interferon Interleukin 12 Interferon gamma Interleukin 6 Interleukin-1 family ClinicalTrials.gov |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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