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| Content Provider | PubMed Central |
|---|---|
| Author | Törn, Carina Liu, Xiang Hagopian, William Lernmark, Åke Olli, Simell Marian, Rewers Ziegler, Anette-g Schatz, Desmond Akolkar, Beena Suna, Onengut-gumuscu Chen, Wei-min Toppari, Jorma Mykkänen, Juha Ilonen, Jorma Rich, Stephen S. She, Jin-xiong Sharma, Ashok Steck, Andrea Krischer, Jeffrey Michael, Abbondondolo Adams, Janey Adamsson, Annika Agardh, Daniel Anderson, Stephen W. Aronsson, Carin Andrén Ask, Maria Sarah, Austin-gonzalez Ayres, Stephen Baethke, Sandra Bautista, Kimberly Baxter, Judith Becker, Dorothy Ruth, Bedoy Bennet, Rasmus Johnson, Suzanne Bennett Beyerlein, Andreas Bonifacio, Ezio Bourcier, Kasia Bremer, Jenny Briese, Thomas Brown, Rasheedah Burkhardt, Brant Butterworth, Martha Carlsson, Ulla-marie Cilio, Corrado Clasen, Joanna Crouch, Claire Cowen Cuthbertson, David Daftary, Ashi Dalmagro-elias, Maryellen Dunson, Kayleen Eberhard, Christopher Larsson, Helena Elding Ericsson-hallström, Emelie Daniel, Felipe-morales Fiske, Steven Foghis, Gabriella Kristina, Foterek Margaret, Fransiscus Fransson, Lina Frohnert, Brigitte I. Garcia, Dena Gard, Thomas Gardiner, Melissa Jennifer, Garmeson Joanna, Gerardsson Gesualdo, Patricia Gowda, Veena Haller, Michael Hansen, Monica Hansson, Gertie Cecilia, Harmby Hervey, Rachel Heyman, Kathleen Hoffman, Michelle Hopkins, Diane Hummel, Michael Hummel, Sandra Hyberg, Susanne Hyöty, Heikki Johansen, Fredrik Johnson, Corbin Sanna, Jokipuu Berglind, Jonasdottir Kallio, Tiina Karban, Rachel Kersting, Mathilde Killian, Michael Klein, Beth Knip, Mikael Knopff, Annette Koivu, Annika Koletzko, Sibylle Koreasalo, Mirva Kalle, Kurppa Kähönen, Miia Lee, Hye-seung Forss, Sigrid Lenrick Liu, Edwin Liu, Shu Lundgren, Markus Lynch, Kristian Lyons, Rachel Lönnrot, Maria Malloy, Jamie Maria, Markan Mccarthy, Cristina Mcindoe, Richard Mcleod, Wendy Melin, Jessica Mestan, Zeliha Meulemans, Steven Meyer, Arlene Mulenga, Denise Multasuo, Katja Maria, Månsson-martinez Mäntimäki, Elina Niinien, Tiina Norris, Jill Nyblom, Mia Peplow, Claudia Perez, Laras Francisco Rahmati, Kobra Rajala, Petra Anita, Ramelius Rautanen, Jenna Anne, Riikonen Robinson, Richard Romo, Minna Rosenquist, Anna Roth, Roswith Salami, Falastin Adela, Samper-imaz Scott, Elisabeth Shaffer, Chris Sibthorpe, Sara Silvis, Katherine Simell, Satu Ville, Simell Sjöberg, Maija Sjöberg, Birgitta Skidmore, Jennifer Smith, Laura Smith, Susan Joshua, Stabbert Steed, Leigh Stenius, Aino Stock, Joanna Strauss, Elisabeth Sulman, Noah Swartling, Ulrica Maria, Särmä Tamura, Roy Tarr, Alexander Amboh, Evelyn Tekum Thomas, Jamie Triplett, Eric Trulsson, Erika Morgan, Uland Uusitalo, Ulla Sini, Vainionpää Wallin, Anne Varionen, Eeva Warncke, Katharina Waugh, Kathleen Kendra, Vehik Veijola, Riitta Vijayakandipan, Ponni Williams, Joshua Willis, John Wimar, Åsa Winkler, Christiane Virtanen, Suvi M. Wood, Keith Wright, Hali Mari, Vähä-mäkilä Yang, Jimin Yates, Chrystal Åberg, Sofie Åkerlund, Mari |
| Copyright Year | 2016 |
| Abstract | A total of 15 SNPs within complement genes and present on the ImmunoChip were analyzed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A total of 5474 subjects were followed from three months of age until islet autoimmunity (IA: n = 413) and the subsequent onset of type 1 diabetes (n = 115) for a median of 73 months (IQR 54–91). Three SNPs within ITGAM were nominally associated (p < 0.05) with IA: rs1143678 [Hazard ratio; HR 0.80; 95% CI 0.66–0.98; p = 0.032], rs1143683 [HR 0.80; 95% CI 0.65–0.98; p = 0.030] and rs4597342 [HR 1.16; 95% CI 1.01–1.32; p = 0.041]. When type 1 diabetes was the outcome, in DR3/4 subjects, there was nominal significance for two SNPs: rs17615 in CD21 [HR 1.52; 95% CI 1.05–2.20; p = 0.025] and rs4844573 in C4BPA [HR 0.63; 95% CI 0.43–0.92; p = 0.017]. Among DR4/4 subjects, rs2230199 in C3 was significantly associated [HR 3.20; 95% CI 1.75–5.85; p = 0.0002, uncorrected] a significance that withstood Bonferroni correction since it was less than 0.000833 (0.05/60) in the HLA-specific analyses. SNPs within the complement genes may contribute to IA, the first step to type 1 diabetes, with at least one SNP in C3 significantly associated with clinically diagnosed type 1 diabetes. |
| Related Links | http://dx.doi.org/10.1038/srep27887 |
| Starting Page | 27887 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 6 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-06-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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