NDLI: Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

Content Provider	PubMed Central
Author	Aho, Vilma Ollila, Hanna M. Kronholm, Erkki Isabel, Bondia-pons Soininen, Pasi Kangas, Antti J. Mika, Hilvo Seppälä, Ilkka Kettunen, Johannes Oikonen, Mervi Emma, Raitoharju Hyötyläinen, Tuulia Mika, Kähönen Viikari, Jorma S. A. Mikko, Härmä Sallinen, Mikael Olkkonen, Vesa M. Alenius, Harri Matti, Jauhiainen Paunio, Tiina Lehtimäki, Terho Salomaa, Veikko Orešič, Matej Raitakari, Olli T. Mika, Ala-korpela Porkka-heiskanen, Tarja
Copyright Year	2016
Abstract	Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
Related Links	http://dx.doi.org/10.1038/srep24828
Starting Page	24828
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	6
Language	English
Publisher	Nature Publishing Group
Publisher Date	2016-04-22
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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