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| Content Provider | PubMed Central |
|---|---|
| Author | Yu, Nam-kyung Kim, Hyoung F. Shim, Jaehoon Kim, Somi Kim, Dae Won Kwak, Chuljung Sim, Su-eon Choi, Jun-hyeok Ahn, Seohee Yoo, Juyoun Choi, Sun-lim Jang, Deok-jin Lim, Chae-seok Lee, Yong-seok Kang, Chulhun Choi, Soo Young Kaang, Bong-kiun |
| Copyright Year | 2016 |
| Abstract | Cell-permeable proteins are emerging as unconventional regulators of signal transduction and providing a potential for therapeutic applications. However, only a few of them are identified and studied in detail. We identify a novel cell-permeable protein, mouse LLP homolog (mLLP), and uncover its roles in regulating neural development. We found that mLLP is strongly expressed in developing nervous system and that mLLP knockdown or overexpression during maturation of cultured neurons affected the neuronal growth and synaptic transmission. Interestingly, extracellular addition of mLLP protein enhanced dendritic arborization, demonstrating the non-cell-autonomous effect of mLLP. Moreover, mLLP interacts with CCCTC-binding factor (CTCF) as well as transcriptional machineries and modulates gene expression involved in neuronal growth. Together, these results illustrate the characteristics and roles of previously unknown cell-permeable protein mLLP in modulating neural development. |
| Related Links | http://dx.doi.org/10.1038/srep22892 |
| Starting Page | 22892 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 6 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-03-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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