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| Content Provider | PubMed Central |
|---|---|
| Author | Deming, Yuetiva Xia, Jian Cai, Yefei Lord, Jenny Del Aguila, Jorge L. Fernandez, Maria Victoria Carrell, David Black, Kathleen Budde, John Ma, Shengmei Benjamin, Saef Howells, Bill Bertelsen, Sarah Bailey, Matthew Ridge, Perry G. Hefti, Franz Howard, Fillit Zimmerman, Earl A. Celmins, Dzintra Brown, Alice D. Carrillo, Maria Fleisher, Adam Reeder, Stephanie Trncic, Nadira Burke, Anna Pierre, Tariot Reiman, Eric M. Chen, Kewei Sabbagh, Marwan N. Beiden, Christine M. Jacobson, Sandra A. Sirrel, Sherye A. Doody, Rachelle S. Javier, Villanueva-meyer Chowdhury, Munir Rountree, Susan Dang, Mimi Kowall, Neil Killiany, Ronald Budson, Andrew E. Alexander, Norbash Johnson, Patricia Lynn Green, Robert C. Marshall, Gad Johnson, Keith A. Sperling, Reisa A. Snyder, Peter Stephen, Salloway Malloy, Paul Correia, Stephen Bernick, Charles Donna, Munic Stern, Yaakov Honig, Lawrence S. Bell, Karen L. Relkin, Norman Gloria, Chaing Lisa, Ravdin Paul, Steven Flashman, Laura A. Seltzer, Marc Hynes, Mary L. Santulli, Robert B. Bates, Vernice Capote, Horacio Michelle, Rainka Friedl, Karl Doraiswamy, P. Murali Petrella, Jeffrey R. Salvador, Borges-neto James, Olga Wong, Terence Coleman, Edward Schwartz, Adam Cellar, Janet S. Levey, Allan L. Lah, James J. Behan, Kelly Turner, Raymond Scott Johnson, Kathleen Reynolds, Brigid Pearlson, Godfrey D. Blank, Karen Anderson, Karen Obisesan, Thomas O. Wolday, Saba Allard, Joanne Lerner, Alan Paula, Ogrocki Curtis, Tatsuoka Fatica, Parianne Farlow, Martin R. Saykin, Andrew J. Foroud, Tatiana M. Shen, Li Faber, Kelly Kim, Sungeun Nho, Kwangsik Hake, Ann Marie Matthews, Brandy R. Brosch, Jared R. Herring, Scott Hunt, Cynthia Albert, Marilyn Onyike, Chiadi D’agostino, Daniel Kielb, Stephanie Graff-radford, Neill R. Parfitt, Francine Kendall, Tracy Johnson, Heather Petersen, Ronald Jack, Clifford R. Bernstein, Matthew Borowski, Bret Gunter, Jeff Senjem, Matt Vemuri, Prashanthi Jones, David Kantarci, Kejal Ward, Chad Mason, Sara S. Albers, Colleen S. David, Knopman Johnson, Kris Howard, Chertkow Hosein, Chris Mintzer, Jacob Spicer, Kenneth Bachman, David Grossman, Hillel Mitsis, Effie Pomara, Nunzio Hernando, Raymundo Antero, Sarrael Potter, William Buckholtz, Neil Hsiao, John Kittur, Smita Galvin, James E. Cerbone, Brittany Michel, Christina A. Pogorelec, Dana M. Henry, Rusinek Leon, Mony J. De Glodzik, Lidia Santi, Susan De Johnson, Nancy Diana, Chuang-kuo Kerwin, Borna Sandra, Bonakdarpour Weintraub, Jordan Grafman, Kristine Lipowski, Marek-marsel Mesulam, Douglas W. Maria, Scharre Kataki, Anahita Adeli, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Michael Borrie, T-y Lee, Rob Bartha, Walter Martinez, Teresa Villena, Carl Sadowsky, Zaven Khachaturian, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Richard Frank, Debra Fleischman, Konstantinos Arfanakis, Raj C. Shah, Leyla Greg, Detoledo-morrell Sorensen, Elizabeth Finger, Stephen Pasternack, Irina Dick, Rachinsky Drost, John Rogers, Andrew Kertesz, Ansgar J. Furst, Stevan Chad, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-yuek Hsiung, Benita Robin Mudge, Michele Nick, Assaly Fox, Susan K. Schultz, Laura L. Ponto, Hyungsub Boles Shim, Karen Smith, Jeffrey M. Ekstam Burns, Russell H. Swerdlow, William M. Brooks, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Love, Charles Natelson Decarli, Owen Carmichael, John Pauline, Olichney Maillard, Evan Fletcher, Dana Nguyen, Andrian Preda, Steven Potkin, Ruth A. Gaby, Mulnard Thai, Catherine Susan, Mcadams-ortiz Landau, William Liana, Jagust Kathleen, Apostolova Ellen, Tingus Woo, Daniel H. S. Silverman, Po H. Lu, George Paul, Bartzokis Thompson, Michael Donohue, Ronald G. Thomas, Sarah Walter, Devon Gessert, James Brewer, Helen Vanderswag, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian, Jennifer Mason, Iris Sim, Paul Aisen, Melissa Davis, Rosemary Morrison, Danielle Harvey, Lean Thal, Laurel Beckett, Thomas Neylan, Shannon Finley, Michael W. Weiner, Jacqueline Hayes, Howard J. Rosen, Bruce L. Miller, David Perry, Dino Massoglia, Olga Norbert, Brawman-mentzer Schuff, Charles D. Smith, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Robert A. Koeppe, Joanne L. Lord, Judith L. Heidebrink, Steven E. Arnold, Jason H. David, Karlawish Wolk, Christopher M. Clark, John Q. Trojanowki, Leslie M. Shaw, Virginia Lee, Magdalena Michal, Korecka Figurski, Arthur W. Toga, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Mauricio, Pawluczyk Liberty, Beccera Teodoro, Bryan M. Spann, Kyle Womack, Dana Mathews, Mary Quiceno, Norm Foster, Tom Jay, Montine J. Fruehling, Sandra Harding, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Eric C. Petrie, Elaine Peskind, Gail Li, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Amanda Smith, Balebail Raj, Kristin Ashok Fargher, Lew Kuller, Chet Mathis, Mary Oakley, Oscar L. Ann Lopez, Donna M. Simpson, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Nigel J. Cairns, Marc Raichle, John C. Morris, Erin Householder, Lisa David, Taylor-reinwald Holtzman, Beau Maria, Ances Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Pradeep Varma, Martha G. Macavoy, Richard E. Carson, Christopher H. Dyck, Peter Van Davies, David Holtzman, John C. Morris, Kelly Bales, Eve H. Pickering, Jin-moo Lee, Laura John, Heitsch Alison, Kauwe Goate, Laura Piccio, Carlos |
| Copyright Year | 2016 |
| Abstract | Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes, and multiple sclerosis. These data suggest that these plasma protein levels may constitute informative endophenotypes for these complex traits. We found three potential pleiotropic genes: ABO for plasma SELE and ACE levels, FUT2 for CA19-9 and CEA plasma levels, and APOE for ApoE and CRP levels. We also found multiple independent signals in loci associated with plasma levels of ApoH, CA19-9, FetuinA, IL6r, and LPa. Our study highlights the power of biological traits for genetic studies to identify genetic variants influencing clinically relevant traits, potential pleiotropic effects, and complex disease associations in the same locus. |
| Related Links | http://dx.doi.org/10.1038/srep18092 |
| Starting Page | 18092 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 6 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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