NDLI: Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference

Content Provider	PubMed Central
Author	Ni, Xumin Yang, Xiong Guo, Wei Yuan, Kai Zhou, Ying Ma, Zhiming Xu, Shuhua
Copyright Year	2016
Abstract	The length of ancestral tracks decays with the passing of generations which can be used to infer population admixture histories. Previous studies have shown the power in recovering the histories of admixed populations via the length distributions of ancestral tracks even under simple models. We believe that the deduction of length distributions under a general model will greatly elevate the power. Here we first deduced the length distributions under a general model and proposed general principles in parameter estimation and model selection with the deduced length distributions. Next, we focused on studying the length distributions and its applications under three typical special cases. Extensive simulations showed that the length distributions of ancestral tracks were well predicted by our theoretical framework. We further developed a new method, AdmixInfer, based on the length distributions and good performance was observed when it was applied to infer population histories under the three typical models. Notably, our method was insensitive to demographic history, sample size and threshold to discard short tracks. Finally, good performance was also observed when applied to some real datasets of African Americans, Mexicans and South Asian populations from the HapMap project and the Human Genome Diversity Project.
Related Links	http://dx.doi.org/10.1038/srep20048
Starting Page	20048
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	6
Language	English
Publisher	Nature Publishing Group
Publisher Date	2016-01-28
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Corrigendum: Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference

Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference

Corrigendum: Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference

Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference

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