NDLI: Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

Content Provider	PubMed Central
Author	Zylicz, Jan J. Dietmann, Sabine Günesdogan, Ufuk Hackett, Jamie A. Cougot, Delphine Lee, Caroline Surani, M. Azim
Editor	Akhtar, Asifa
Copyright Year	2015
Abstract	Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development. Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, and coincides with redistribution of enhancer of zeste homolog 2 (EZH2)-dependent histone H3 lysine 27 trimethylation (H3K27me3). Loss of G9a or EZH2 results in upregulation of distinct gene sets involved in cell cycle regulation, germline development and embryogenesis. Notably, the H3K9me2 modification extends to active enhancer elements where it promotes developmentally-linked gene silencing and directly marks promoters and gene bodies. This epigenetic mechanism is important for priming gene regulatory networks for critical cell fate decisions in rapidly proliferating postimplantation epiblast cells.
Related Links	http://dx.doi.org/10.7554/elife.09571
Starting Page	9571
File Format	PDF
ISSN	2050084X
e-ISSN	2050084X
Journal	eLife
Volume Number	4
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2015-11-01
Access Restriction	Open
Rights Holder	eLife Sciences Publications, Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

CpG methylation, chromatin structure and gene silencing-a three-way connection.

Dimerization of the largest subunit of chromatin assembly factor 1: importance in vitro and during Xenopus early development

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots' during early adipogenesis

Time-Lapse Dynamics of the Mouse Oocyte Chromatin Organisation during Meiotic Resumption

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing

Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

Similar Documents

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

CpG methylation, chromatin structure and gene silencing-a three-way connection.

Dimerization of the largest subunit of chromatin assembly factor 1: importance in vitro and during Xenopus early development

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots' during early adipogenesis

Time-Lapse Dynamics of the Mouse Oocyte Chromatin Organisation during Meiotic Resumption

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing

Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development