NDLI: Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

Content Provider	PubMed Central
Author	Woo, Yong H. Ansari, Hifzur Otto, Thomas D. Klinger, Christen M. Kolisko, Martin Michálek, Jan Saxena, Alka Shanmugam, Dhanasekaran Tayyrov, Annageldi Veluchamy, Alaguraj Ali, Shahjahan Bernal, Axel Campo, Javier Del Cihlář, Jaromír Pavel, Flegontov Gornik, Sebastian G. Eva, Hajdušková Horák, Aleš Jan, Ouškovec Katris, Nicholas J. Mast, Fred D. Diego, Miranda-saavedra Mourier, Tobias Naeem, Raeece Nair, Mridul Panigrahi, Aswini K. Rawlings, Neil D. Padron-regalado, Eriko Ramaprasad, Abhinay Samad, Nadira Tomčala, Aleš Wilkes, Jon Neafsey, Daniel E. Christian, Doerig Bowler, Chris Keeling, Patrick J. Roos, David S. Dacks, Joel B. Templeton, Thomas J. Waller, Ross F. Lukeš, Julius Oborník, Miroslav Pain, Arnab
Editor	Magnus, Nordborg
Copyright Year	2015
Abstract	The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga.
Related Links	http://dx.doi.org/10.7554/eLife.06974
Starting Page	6974
File Format	PDF
ISSN	2050084X
e-ISSN	2050084X
Journal	eLife
Volume Number	4
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2015-07-15
Access Restriction	Open
Rights Holder	eLife Sciences Publications, Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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