NDLI: Additive effects on the energy barrier for synaptic vesicle fusion causesupralinear effects on the vesicle fusion rate

Content Provider	PubMed Central
Author	Schotten, Sebastiaan Meijer, Marieke Walter, Alexander Matthias Huson, Vincent Mamer, Lauren Lawrence, Kalogreades Veer, Mirelle Ter Ruiter, Marvin Brose, Nils Rosenmund, Christian Balslev, SÃ¸rensen Jakob Verhage, Matthijs Cornelisse, Lennart Niels
Editor	Häusser, Michael
Copyright Year	2015
Abstract	The energy required to fuse synaptic vesicles with the plasma membrane(‘activation energy’) is considered a major determinant in synapticefficacy. From reaction rate theory, we predict that a class of modulations exists,which utilize linear modulation of the energy barrier for fusion to achievesupralinear effects on the fusion rate. To test this prediction experimentally, wedeveloped a method to assess the number of releasable vesicles, rate constants forvesicle priming, unpriming, and fusion, and the activation energy for fusion byfitting a vesicle state model to synaptic responses induced by hypertonic solutions.We show that complexinI/II deficiency or phorbol ester stimulation indeed affectsresponses to hypertonic solution in a supralinear manner. An additive vsmultiplicative relationship between activation energy and fusion rate provides anovel explanation for previously observed non-linear effects ofgenetic/pharmacological perturbations on synaptic transmission and a novelinterpretation of the cooperative nature of Ca2+-dependentrelease.
Related Links	http://dx.doi.org/10.7554/elife.05531
Starting Page	5531
File Format	PDF
ISSN	2050084X
e-ISSN	2050084X
Journal	eLife
Volume Number	4
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2015-04-01
Access Restriction	Open
Rights Holder	eLife Sciences Publications, Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

Correction: Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Adaptin' endosomes for synaptic vesicle recycling, learning and memory

Additive effects on the energy barrier for synaptic vesicle fusion causesupralinear effects on the vesicle fusion rate

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Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

Correction: Modification of a Hydrophobic Layer by a Point Mutation in Syntaxin 1A Regulates the Rate of Synaptic Vesicle Fusion

Adaptin' endosomes for synaptic vesicle recycling, learning and memory

Additive effects on the energy barrier for synaptic vesicle fusion causesupralinear effects on the vesicle fusion rate