NDLI: Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

Content Provider	PubMed Central
Author	Gray, Andrew N. Egan, Alexander Jf Veer, Inge L. Van't Verheul, Jolanda Alexandre, Colavin Alexandra, Koumoutsi Jacob, Biboy Altelaar, A. F. Maarten Damen, Mirjam J. Huang, Kerwyn Casey Jean-pierre, Simorre Breukink, Eefjan Den, Blaauwen Tanneke Athanasios, Typas Gross, Carol A. Vollmer, Waldemar
Editor	Storz, Gisela
Copyright Year	2015
Abstract	To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that envelope machines facilitating septal PG synthesis (PBP1B-LpoB complex) and OM constriction (Tol system) are physically and functionally coordinated via YbgF, renamed CpoB (Coordinator of PG synthesis and OM constriction, associated with PBP1B). CpoB localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction, interacts with both complexes, and regulates PBP1B activity in response to Tol energy state. This coordination links PG synthesis with OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modulating PBP1B cross-linking activity. Coordination of the PBP1B and Tol machines by CpoB contributes to effective PBP1B function in vivo and maintenance of cell envelope integrity during division.
Related Links	http://dx.doi.org/10.7554/elife.07118
Starting Page	7118
File Format	PDF
ISSN	2050084X
e-ISSN	2050084X
Journal	eLife
Volume Number	4
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2015-05-01
Access Restriction	Open
Rights Holder	eLife Sciences Publications, Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli

A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface

Location of some proteins involved in peptidoglycan synthesis and cell division in the inner and outer membranes of Escherichia coli.

Rate and topography of peptidoglycan synthesis during cell division in Escherichia coli: concept of a leading edge.

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli.

The trans-envelope Tol–Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli

Direct interaction of FtsZ and MreB is required for septum synthesis and cell division in Escherichia coli

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

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Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli

A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface

Location of some proteins involved in peptidoglycan synthesis and cell division in the inner and outer membranes of Escherichia coli.

Rate and topography of peptidoglycan synthesis during cell division in Escherichia coli: concept of a leading edge.

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli.

The trans-envelope Tol–Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli

Direct interaction of FtsZ and MreB is required for septum synthesis and cell division in Escherichia coli

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division