NDLI: Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

Content Provider	PubMed Central
Author	Bellay, Timothy Klaus, Andreas Seshadri, Saurav Dietmar, Plenz
Editor	Skinner, Frances K.
Abstract	Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity.
Related Links	http://dx.doi.org/10.7554/elife.07224
Starting Page	7224
File Format	PDF
ISSN	2050084X
e-ISSN	2050084X
Journal	eLife
Volume Number	4
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2015-07-01
Access Restriction	Open
Rights Holder	eLife Sciences Publications, Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

A unified theory of E/I synaptic balance, quasicritical neuronal avalanches and asynchronous irregular spiking

SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons (Dataset)

IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons

Time-Warp–Invariant Neuronal Processing

Neurons for Numerosity: As Quantities Increase, So Does the Neuronal Response

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

Similar Documents

Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

A unified theory of E/I synaptic balance, quasicritical neuronal avalanches and asynchronous irregular spiking

SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons (Dataset)

IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons

Time-Warp–Invariant Neuronal Processing

Neurons for Numerosity: As Quantities Increase, So Does the Neuronal Response

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state