NDLI: Surface modification of titanium with chitosan-heparin multilayers via electrostatic self-assembly technique

Content Provider	IEEE Xplore Digital Library
Author	Zhennan Deng Dafeng Zhang Haoyuan Huang Jianfeng Ma
Copyright Year	2010
Description	Author affiliation: School & Hospital of Stomatology, Wenzhou Medical College, 325027, China (Zhennan Deng; Dafeng Zhang; Jianfeng Ma) \|\| Integrated Traditional & Western Medicine Hospital, Chengdu, 610000, China (Haoyuan Huang)
Abstract	To improve the surface biocompatibility of titanium films, a electrostatic self-assembly technique (ESA), based on the polyelectrolyte-mediated electrostatic adsorption of chitosan (Chi) and heparin (Hep), was used leading to the formation of multilayers on the titanium thin film surfaces. The film growth was initialized by depositing one layer of positively charged poly-L-lysine (PLL) on the NaOH-treated titanium substrate (negatively charged surface). Then the film was formed by the alternate deposition of negatively charged heparin and positively charged chitosan via electrostatic interactions of polyelectrolytes, and terminated by an outermost layer of chitosan. The ESA film was monitored by several techniques. The chemical composition and surface topography were investigated by using diffuse reflectance Fourier transform infrared spectroscopy (DR-FTIR), scanning electron microscope (SEM) and atomic force microscope (AFM), respectively. The results indicated that a full surface coverage for the outmost layer was achieved after deposition of sixteen layers. Cell morphology, cell proliferation as well as differentiation function (alkaline phosphatase) of osteoblasts on ESA-modified titanium film (PLL/(Hep/Chi)16) and control sample were investigated, respectively. Osteoblasts cultured on ESA-modified titanium film showed better morphology than that of control. Cell proliferation and alkaline phosphatase measurements indicated that osteoblasts on ESA-modified titanium films were greater (p<0.01) than those for the control, respectively. These results suggested that surface modification of titanium was successfully achieved via deposition of PLL/(Hep/Chi)16 layers, which was useful to enhance the biocompatibility of the titanium film. The approach presented here may be exploited for fabrication of titanium-based implant surfaces.
Starting Page	1731
Ending Page	1735
File Size	2291335
Page Count	5
File Format	PDF
ISBN	9781424464951
e-ISBN	9781424464982
DOI	10.1109/BMEI.2010.5639913
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	surface engineering chitosan Films Surface morphology titanium Surface topography Phase locked loops Surface treatment heparin cell biocompatibility Morphology Titanium electrostatic self-assembly technique
Content Type	Text
Resource Type	Article

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