NDLI: Acoustic detection of laser induced optical breakdown in dendrimer nanocomposites: implications for site targeted molecular diagnostics and therapeutics

Content Provider	IEEE Xplore Digital Library
Author	O'Donnell, M. Milas, S.M. Ye, J.Y. Norris, T.B. Balogh, L.P. Baker Jr., J.R. Hollman, K. Emelianov, S.Y.
Copyright Year	2002
Description	Author affiliation: Biomed. Eng. Dept., Michigan Univ., Ann Arbor, MI, USA (O'Donnell, M.; Milas, S.M.)
Abstract	Laser-induced optical breakdown (LIOB) attained at the focus of a femtosecond laser leads to nonlinear energy absorption and measurable secondary effects that include shock-wave emission, heat transfer, and bubble formation. A real-time acoustic technique has been developed to characterize LIOB thresholds in tissue-like materials regardless of their optical transparency. With LIOB, a bubble forms resulting in a high velocity shock-wave propagating spherically outward from the effective point source. This wave can be detected acoustically. In addition, the optical focal zone is actively probed with acoustic pulse-echo measurements to monitor formed bubbles. The power of 50-100 MHz acoustic waves reflected from the bubbles can quantify differences between non-breakdown and breakdown events. Using this technique, two dendrimer nanocomposites (DNC) have been evaluated as potential site targeted diagnostic/therapeutic agents. The LIOB threshold was 50 mW (200 nJ/pulse) for a bare DNC system and a reduced threshold of 4 mW (15 nJ/pulse) for an Ag-loaded DNC system. These results suggest that metal-loaded DNC systems may be efficient site targeted diagnostic/therapeutic agents. In addition, their action can be sensitively monitored using high frequency ultrasound imaging.
Sponsorship	Ultransonics Ferroelectr., & Frequency Control Soc
Starting Page	1961
Ending Page	1964
File Size	151445
Page Count	4
File Format	PDF
ISBN	0780375823
ISSN	10510117
DOI	10.1109/ULTSYM.2002.1192684
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-08
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Acoustic signal detection Electric breakdown Nanocomposites Ultrafast optics Nonlinear optics Optical sensors Stimulated emission Acoustic pulses Acoustic emission Acoustic measurements
Content Type	Text
Resource Type	Article

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