NDLI: In vitro ultrasonic tissue characterization for evaluation of hepatic diseases

Content Provider	IEEE Xplore Digital Library
Author	Abdelwahab, A. Meziri, M. Pereira, W.C.A. Bridal, L. Degott, C. Laugier, P. Grimaud, J.-A.
Copyright Year	2002
Description	Author affiliation: Lab. Imagerie Parametrique, CNRS, Paris, France (Abdelwahab, A.)
Abstract	The objective of this study is to explore the potential of attenuation and ultrasonic (US) velocity estimates (6 to 30 MHz) to discriminate healthy and diseased human liver. Echoes from 47 fresh in vitro samples of human liver and a planer reflector were obtained using a 20-MHz central frequency transducer (scan plane parallel to the reflector placed beneath the liver approximately). Comparisons of echo times-of-flights and echo spectra with and without intervening liver were normalized by local liver thickness to calculate the US velocity and attenuation, respectively (substitution method). Projection parameter images were constructed, and measurements from selected regions of interest were compared with histological classification. The average US velocities were 1540.4 /spl plusmn/ 35.5 m/s, 1579.9 /spl plusmn/ 25.2 m/s, 1584.4 /spl plusmn/ 35.1 m/s for normal (N = 13), cancerous (N = 8) and fibrotic (N = 26) groups, respectively. Significant velocity differences were found between the normal group and both pathological groups, (p<0.01). However, US velocity failed to differentiate fibrotic and cancerous groups. Average attenuation slopes were 0.074 /spl plusmn/ 0.016 dB.mm/sup -1/ MHz/sup -1/, 0.098 /spl plusmn/ 0.029 dB.mm/sup -1/ MHz/sup -1/, 0.063 /spl plusmn/ 0.015 dB.mm/sup -1/ MHz/sup -1/ for normal, fibrotic and cancerous groups, respectively and were significantly different between normal and fibrotic (p<0.005) groups and between cancerous and fibrotic groups (p < 10/sup -4/) but not between cancerous and normal groups. However, an outlier was found in the cancerous group. Removing this outlier resulted in a significant difference between cancerous and normal groups (p<0.005). Such high frequency measurements (20 MHz) could potentially be used intra-operatively to identify suspicious focal lesions otherwise difficult to classify with other imaging modalities.
Sponsorship	Ultransonics Ferroelectr., & Frequency Control Soc
Starting Page	1317
Ending Page	1320
File Size	250727
Page Count	4
File Format	PDF
ISBN	0780375823
ISSN	10510117
DOI	10.1109/ULTSYM.2002.1192537
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-08
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vitro Diseases Liver Ultrasonic imaging Attenuation Frequency Lesions Surgery Humans Metalworking machines
Content Type	Text
Resource Type	Article

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