NDLI: The effect of microbubble concentration on thresholds for tissue damage produced by single bursts of high intensity ultrasound during continuous Optison/spl reg/ infusion

Content Provider	IEEE Xplore Digital Library
Author	Tran, B.C. Jongbum Soo Fowlkes, J.B. Cain, C.A.
Copyright Year	2002
Description	Author affiliation: Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA (Tran, B.C.; Jongbum Soo; Fowlkes, J.B.; Cain, C.A.)
Abstract	The presence of ultrasound contrast agent (stabilized microbubbles) during high intensity focused ultrasound insonation can reduce both the exposure intensity and duration required for producing macroscopic tissue damage. In this paper, we evaluate the enhancement produced by Optison/spl reg/ infusion at concentrations of 0, 0.1, 0.3, 1, 3, and 10 /spl mu/L/kg/min. Acute canine kidneys were surgically externalized and insonified with single ultrasound exposures. The probability of tissue damage production was determined with respect to exposure intensity and duration for each concentration. As microbubble concentration increased from 0 to 10 /spl mu/L/kg/min, the requisite intensity and the requisite duration both gradually decreased. The results indicate that microbubble introduction up to 10 /spl mu/L/kg/min is effective for aiding ultrasound therapy.
Sponsorship	Ultransonics Ferroelectr., & Frequency Control Soc
Starting Page	1411
Ending Page	1414
File Size	404877
Page Count	4
File Format	PDF
ISBN	0780375823
ISSN	10510117
DOI	10.1109/ULTSYM.2002.1192560
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-08
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Tissue damage Ultrasonic imaging Medical treatment Focusing Ultrasonic transducers Surgery Water heating Acoustic transducers Biomedical engineering Production
Content Type	Text
Resource Type	Article

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