NDLI: The measurement of backscatter from individual contrast agent microbubbles

Content Provider	IEEE Xplore Digital Library
Author	Sboros, V. Pye, S.D. Anderson, T. Moran, C.M. Averkiou, M. MacDonald, C.A. Gomatam, J.
Copyright Year	2002
Description	Author affiliation: Dept. of Med. Phys. & Med. Eng., Edinburgh Univ., UK (Sboros, V.; Pye, S.D.; Anderson, T.; Moran, C.M.)
Abstract	In vitro experimentation still has some way to go to achieve a thorough understanding of the dynamic properties of microbubbles. This paper describes an experiment to detect RF backscatter from individual microbubbles using a hydrodynamically focused flow. A fine capillary was placed at the centre of the focused flow and single microbubbles were released along a precise vertical path coincident with the axis of the ultrasound beam. Six period pulses were used in combination with two different pulse amplitudes (550 kPa and 980 kPa p.p.). The RF signal intensities of individual scattering events for the contrast agent Definity were calculated and normalised using calibration data previously obtained from solid copper particles. The usable receive frequency range of the system was 1.0-4.5 MHz. At 550 kPa, a dominant resonance was observed at a transmit frequency of 1.5 MHz for both the fundamental and second harmonic backscatter. At 980 kPa the fundamental backscatter increased monotonically with transmit frequency, whilst the second harmonic backscatter was almost independent of transmit frequency. The experimental system demonstrates considerable flexibility of control and the ability to produce a large output of backscatter data from individual microbubbles.
Sponsorship	Ultransonics Ferroelectr., & Frequency Control Soc
Starting Page	1945
Ending Page	1947
File Size	1667401
Page Count	3
File Format	PDF
ISBN	0780375823
ISSN	10510117
DOI	10.1109/ULTSYM.2002.1192680
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-08
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Backscatter In vitro Radio frequency Ultrasonic imaging Particle scattering Calibration Solids Copper Resonance Control systems
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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