NDLI: Optically observed microbubble coalescence and collapse

Content Provider	IEEE Xplore Digital Library
Author	Postema, M. Bouakaz, A. Chien Ting Chin de Jong, N.
Copyright Year	2002
Description	Author affiliation: Dept. of Exp. Echocardiography, Erasmus Univ. Med. Center, Rotterdam, Netherlands (Postema, M.; Bouakaz, A.; Chien Ting Chin; de Jong, N.)
Abstract	Understanding the mechanisms of microbubble destruction is needed for the development of ultrasound guided drug and gene delivery methods and for the improvement of diagnostic ultrasonic contrast agent (UCA) detection methods. We performed 482 experiments on the coalescence and collapse mechanisms of a soft-shelled and a hard-shelled contrast agent, by subjecting an experimental lipid-shelled UCA and the hard-shelled UCA Quantison/spl trade/ to 500 kHz, high-pressured ultrasound (MI/spl ap/1.0), and recording microscopic images of these events with a fast-framing camera. Results showed that bubble fragmentation into smaller bubbles is the primary mechanism for lipid-shelled contrast microbubble destruction during the first cycles after ultrasound arrival. In 28% of our experimental events with a lipid-shelled UCA, we observed bubble coalescence. The coalescence mechanism was observed to be analog to the process described for larger gas bubbles. Repetitive coalescence and fragmentation was clearly recorded with a fast-framing camera. We also demonstrated the formation and collapse of large lipid-shelled bubbles and bubble clusters. Furthermore we showed that sonic cracking is feasible for the hard-shelled contrast agent Quantison/spl trade/.
Sponsorship	Ultransonics Ferroelectr., & Frequency Control Soc
Starting Page	1949
Ending Page	1952
File Size	275762
Page Count	4
File Format	PDF
ISBN	0780375823
ISSN	10510117
DOI	10.1109/ULTSYM.2002.1192681
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-08
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Cameras Drugs Optical recording Microscopy In vitro Ultrasonic transducers Biomedical optical imaging Echocardiography Biomedical imaging
Content Type	Text
Resource Type	Article

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