NDLI: Computer simulations of dorsal cochlear nucleus neural circuitry

Content Provider	IEEE Xplore Digital Library
Author	Hancock, K.E. Davis, K.A. Voigt, H.F.
Copyright Year	2001
Description	Author affiliation: Eaton-Peabody Lab., Massachusetts Eye & Ear Infirmary, Boston, MA, USA (Hancock, K.E.)
Abstract	The dorsal cochlear nucleus (DCN) is part of the first stage of auditory processing in the central nervous system. Experimental evidence has provided a conceptual model for a portion of the DCN neural circuit that serves as a basis for the computational model described in this paper. The model consists of four neural populations arranged tonotopically. The pattern of convergence from one population to another and the strengths of those connections are important model parameters. Lumped parameter electrical circuit models are used to model the membrane potential of individual cells. Synapses are simulated by activating variable conductances in postsynaptic cells according to spike activity in presynaptic cells. The level of detail incorporated in the model is a good compromise between biophysical accuracy and the computational tractability required to simulate relatively large networks. Results are shown demonstrating the ability of the model to replicate features of DCN cross-correlation functions and to simulate DCN response properties with quantitative accuracy. The model is a useful tool for exploring hypotheses regarding DCN structure and function.
Starting Page	666
Ending Page	669
File Size	295333
Page Count	4
File Format	PDF
ISBN	0780372115
ISSN	1094687X
DOI	10.1109/IEMBS.2001.1019023
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-10-25
Publisher Place	Turkey
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computer simulation Computational modeling Circuit simulation Acoustic noise Biomedical engineering Circuit noise Frequency Wideband Laboratories Ear
Content Type	Text
Resource Type	Article

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