NDLI: Termination of reentrant propagation by a single extracellular stimulus in an atrial ring model

Content Provider	IEEE Xplore Digital Library
Author	Johnson, C.R. Barr, R.C.
Copyright Year	2001
Description	Author affiliation: Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA (Johnson, C.R.; Barr, R.C.)
Abstract	Cardiac reentry, the underlying mechanism of both tachycardia and fibrillation, is often terminated clinically with extracellular stimuli. We developed a one-dimensional mathematical model to find the probability that a short, randomly-timed extracellular stimulus would terminate reentry and to study the mechanisms responsible for termination. Our ring model consisted of 100 atrial cells, with the cell membrane represented mathematically by a model developed by Nygren et al. (1998). Stable reentry was established, and then a single extracellular stimulus with a pulsewidth of either 2.5 msec or 5.0 msec was applied through a cathode positioned over cell 25 and an anode over cell 50. Total delivered charge was kept constant. The timing of the stimulus was varied in 1.0 msec steps so as to sample one complete revolution of the reentering wavefront. The probability that the 2.5 mec stimulus would terminate reentry was 2.8%, 0.2% at the cathode and 2.6% at the anode. The probability of termination increased to 4.2% with the 5.0 msec stimulus (1.5% at the cathode and 2.7% at the anode). The anode was more significant than the cathode in terminating reentry, and the anodal mechanism was less sensitive to the stimulus pulsewidth.
Starting Page	398
Ending Page	401
File Size	354052
Page Count	4
File Format	PDF
ISBN	0780372115
ISSN	1094687X
DOI	10.1109/IEMBS.2001.1018945
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-10-25
Publisher Place	Turkey
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Extracellular Cathodes Anodes Mathematical model Immune system Biomembranes Biomedical engineering Space vector pulse width modulation Heart Electric resistance
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in