NDLI: Vascular adaptations to transverse aortic banding in mice

Content Provider	IEEE Xplore Digital Library
Author	Hartley, C.J. Ochoa, L.N. Reddy, A.K. Michael, L.H. Pocius, J.S. Pham, T.T. Scott, C.W. Entman, M.L. Clark Jr., J.W. Taffet, G.E.
Copyright Year	2001
Description	Author affiliation: Dept. of Medicine, Baylor Coll. of Med., Houston, TX, USA (Hartley, C.J.; Ochoa, L.N.; Reddy, A.K.; Michael, L.H.; Pocius, J.S.; Pham, T.T.; Scott, C.W.; Entman, M.L.)
Abstract	Transverse aortic banding in mice generates pressure overload, but cardiac hypertrophy is variable, and the effects on peripheral hemodynamics are unknown. The purpose was to characterize and model carotid and aortic blood flow patterns in banded mice using noninvasive Doppler methods. In 15 normal mice a 27-gauge needle was sutured against the transverse aorta and then removed. In 6 sham-operated mice the suture was not tied. A Doppler probe was used to measure right (R) and left (L) carotid artery (CA), aortic, and mitral blood velocity 1 day later. At 7 days the heart-weight/body-weight ratio (HW/BW) was measured. Mean aortic, mitral, and carotid velocities were similar in sham and banded mice, but peak RCA/LCA velocities were much higher in banded mice and were highly correlated to HW/BW. An esophageal Doppler probe detected high jet velocity and distal vorticity. We conclude that mice compensate for the band by increasing RCA resistance and compliance and decreasing LCA resistance to maintain normal cerebral perfusion. Velocity signals measured within one day and fitted to a lumped-parameter arterial model to estimate the pressure drop can predict the amount of cardiac hypertrophy at one week.
Starting Page	184
Ending Page	187
File Size	372824
Page Count	4
File Format	PDF
ISBN	0780372115
ISSN	1094687X
DOI	10.1109/IEMBS.2001.1018883
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-10-25
Publisher Place	Turkey
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mice Probes Velocity measurement Hemodynamics Blood flow Needles Carotid arteries Esophagus Electrical resistance measurement Pressure measurement
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in