NDLI: Bioeffect modeling of nonuniform dose distributions for paired organs

Content Provider	IEEE Xplore Digital Library
Author	Markman, J. Deasy, J.O. Chao, K.S. Low, D.A.
Copyright Year	2000
Description	Author affiliation: Washington Univ. Sch. of Med., St. Louis, MO, USA (Markman, J.)
Abstract	Evaluating treatment plans on the basis of risk/benefit to the patient depends on accurate characterization of dose-response distributions from clinical data. Typically, response data is defined as a binary complication variable according to a pre-determined threshold value. This binning of the data into two groups can mask gradual dose-response changes, and may make the dose-response model overly sensitive to the choice of complication threshold. Here, the authors explore two new fitting functions, the Generalized Mills Ratio (GMR) and the log-normal integral (LNI), with the goal of modeling the bioeffect indicator without the use of binning. These new fitting functions give the modeling a wide range of response curves of the type the authors are working with. These functions are applied to dose-response data for parotid glands treated with 3D treatment planning techniques, primarily intensity modulated radiation therapy (IMRT). Stimulated saliva flow 6 months after treatment is used as the bioeffect indicator. Preliminary analysis indicates that for the parotid glands, the lesser of the two mean doses may be an important indicator. In other words, the response may be correlated, and new methods of data analysis are important to analyze the correlation. An example of the computation of confidence intervals is given using bootstrap resampling techniques.
Starting Page	701
Ending Page	705
File Size	219579
Page Count	5
File Format	PDF
ISBN	0780364651
ISSN	1094687X
DOI	10.1109/IEMBS.2000.900843
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-07-23
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Glands Probability distribution Medical treatment Milling machines Fluid flow measurement Chaos Curve fitting Intensity modulation Biomedical applications of radiation Data analysis
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Inverse planning incorporating organ motion

Comparison of beam characteristics in intensity modulated radiation therapy (IMRT) and those under normal treatment condition

Nonuniform dose distribution in normal organs and tissues during radiation therapy of malignant tumors

Comparison of dose distributions from geometric conformation and intensity modulation for intracranial lesions

Monitor unit calculation for intensity modulated photon field

Machine Learning for Modeling Dose-Related Organ-at-Risk Complications after Radiation Therapy

Asymptotically accurate flow completion time distributions under Fair Queueing

Mixing electrons with intensity modulated photon beams to reduce integral dose

Hookup security for synchronous machines

Bioeffect modeling of nonuniform dose distributions for paired organs

Similar Documents

Inverse planning incorporating organ motion

Comparison of beam characteristics in intensity modulated radiation therapy (IMRT) and those under normal treatment condition

Nonuniform dose distribution in normal organs and tissues during radiation therapy of malignant tumors

Comparison of dose distributions from geometric conformation and intensity modulation for intracranial lesions

Monitor unit calculation for intensity modulated photon field

Machine Learning for Modeling Dose-Related Organ-at-Risk Complications after Radiation Therapy

Asymptotically accurate flow completion time distributions under Fair Queueing

Mixing electrons with intensity modulated photon beams to reduce integral dose

Hookup security for synchronous machines

Bioeffect modeling of nonuniform dose distributions for paired organs