NDLI: Dynamic 3D computed tomography: non-invasive method for determination of the aortic dynamic elastic modulus

Content Provider	IEEE Xplore Digital Library
Author	Lee, M.K. Holdsworth, D.W. Fenster, A.
Copyright Year	2000
Description	Author affiliation: John P. Robarts Res. Inst., London, Ont., Canada (Lee, M.K.)
Abstract	A 3D dynamic computed-tomography (CT) scanner was developed for imaging objects undergoing periodic motion. The scanner system has high spatial and sufficient temporal resolution to produce quantitative tomographic/volume images of objects such as excised arterial samples perfused under physiological pressure conditions and enables the measurements of the local dynamic elastic modulus (E/sub dyn/) of the arteries in the axial and longitudinal directions. The system was comprised of a high resolution modified X-ray image intensifier (XRII) based computed tomographic system and a computer-controlled cardiac flow simulator. A standard NTSC CCD camera with a macro lens was coupled to the electro-optically zoomed XRII to acquire dynamic volumetric images. Through prospective cardiac gating and computer synchronized control, a time-resolved sequence of 20 mm thick high resolution volume images of porcine aortic specimens during one simulated cardiac cycle were obtained. Performance evaluation of the scanners illustrated that tomographic images can be obtained with resolution as high as 3.2 mm/sup -1/ with only a 9% decrease in the resolution for objects moving at velocities of 1 cm/s in 2D mode and static spatial resolution of 3.55 mm/sup -1/ with only a 14% decrease in the resolution in 3D mode for objects moving at a velocity of 10 cm/s. Application of the system for imaging of intact excised arterial specimens under simulated physiological flow/pressure conditions enabled measurements of the E/sub dyn/ of the arteries with a precision of /spl plusmn/10 kPa for the 3D scanner. Evaluation of the E/sub dyn/ in the axial and longitudinal direction produced values of 428/spl plusmn/35 kPa and 728/spl plusmn/71 kPa, demonstrating the isotropic and homogeneous viscoelastic nature of the vascular specimens. These values obtained from the Dynamic CT systems were not statistically different (p<0.05) from the values obtained by standard uniaxial tensile testing and volumetric measurements.
Starting Page	661
Ending Page	664
File Size	372044
Page Count	4
File Format	PDF
ISBN	0780364651
ISSN	1094687X
DOI	10.1109/IEMBS.2000.900831
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2000-07-23
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computed tomography Image resolution Spatial resolution Volume measurement Pressure measurement Arteries Computational modeling Computer simulation High-resolution imaging X-ray imaging
Content Type	Text
Resource Type	Article

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